Sodium-coupled monocarboxylate transporter 1: Difference between revisions

SLC5A8
Identifiers
Aliases	SLC5A8, AIT, SMCT, SMCT1, solute carrier family 5 member 8
External IDs	OMIM: 608044; MGI: 2384916; HomoloGene: 64832; GeneCards: SLC5A8; OMA:SLC5A8 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	101,210,238 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	88,765,377 bp
RNA expression pattern
	Top expressed in
	thyroid gland; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; kidney; ; right adrenal gland; ; renal cortex; ; canal of the cervix; ; prostate; ; islet of Langerhans; ; thymus;
	Top expressed in
	left colon; ; proximal tubule; ; olfactory epithelium; ; parotid gland; ; kidney; ; lacrimal gland; ; conjunctival fornix; ; ileum; ; intestinal villus; ; submandibular gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transporter activity; monocarboxylic acid transmembrane transporter activity; passive transmembrane transporter activity; symporter activity; organic acid:sodium symporter activity; lactate transmembrane transporter activity; propionate transmembrane transporter activity; short-chain fatty acid transmembrane transporter activity; transmembrane transporter activity; monocarboxylate:sodium symporter activity;
Cellular component	integral component of membrane; plasma membrane; extracellular exosome; apical plasma membrane; membrane;
Biological process	ion transport; sodium ion transport; apoptotic process; transmembrane transport; monocarboxylic acid transport; NAD biosynthesis via nicotinamide riboside salvage pathway; transport; propanoate transport; short-chain fatty acid import; lactate transmembrane transport; organic acid transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	160728
	216225
	ENSG00000262217; ENSG00000256870
	ENSMUSG00000020062
	Q8N695
	Q8BYF6
	NM_145913
	NM_145423
	NP_666018
	NP_663398
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 01:06, 13 October 2020

Sodium-coupled monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC5A8 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c ENSG00000256870 GRCh38: Ensembl release 89: ENSG00000262217, ENSG00000256870 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020062 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rodriguez AM, Perron B, Lacroix L, Caillou B, Leblanc G, Schlumberger M, Bidart JM, Pourcher T (Jul 2002). "Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes". J Clin Endocrinol Metab. 87 (7): 3500–3. doi:10.1210/jc.87.7.3500. PMID 12107270.
^ Li H, Myeroff L, Smiraglia D, Romero MF, Pretlow TP, Kasturi L, Lutterbaugh J, Rerko RM, Casey G, Issa JP, Willis J, Willson JK, Plass C, Markowitz SD (Jul 2003). "SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers". Proc Natl Acad Sci U S A. 100 (14): 8412–7. doi:10.1073/pnas.1430846100. PMC 166243. PMID 12829793.
^ "Entrez Gene: SLC5A8 solute carrier family 5 (iodide transporter), member 8".

Gupta N, Martin PM, Prasad PD, Ganapathy V (2006). "SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter". Life Sci. 78 (21): 2419–25. doi:10.1016/j.lfs.2005.10.028. PMID 16375929.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Miyauchi S, Gopal E, Fei YJ, Ganapathy V (2004). "Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids". J. Biol. Chem. 279 (14): 13293–6. doi:10.1074/jbc.C400059200. PMID 14966140.
Lacroix L, Pourcher T, Magnon C, et al. (2004). "Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters". J. Clin. Endocrinol. Metab. 89 (3): 1423–8. doi:10.1210/jc.2003-030542. PMID 15001644.
Hong C, Maunakea A, Jun P, et al. (2005). "Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8". Cancer Res. 65 (9): 3617–23. doi:10.1158/0008-5472.CAN-05-0048. PMID 15867356.
Paroder V, Spencer SR, Paroder M, et al. (2006). "Na+/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: Molecular characterization of SMCT". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7270–5. doi:10.1073/pnas.0602365103. PMC 1456061. PMID 16670197.
Hu S, Liu D, Tufano RP, et al. (2006). "Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer". Int. J. Cancer. 119 (10): 2322–9. doi:10.1002/ijc.22110. PMID 16858683. S2CID 45869283.
Gopal E, Miyauchi S, Martin PM, et al. (2007). "Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract". Pharm. Res. 24 (3): 575–84. doi:10.1007/s11095-006-9176-1. PMID 17245649. S2CID 11325302.
Coady MJ, Wallendorff B, Bourgeois F, et al. (2007). "Establishing a Definitive Stoichiometry for the Na+/Monocarboxylate Cotransporter SMCT1". Biophys. J. 93 (7): 2325–31. doi:10.1529/biophysj.107.108555. PMC 1965447. PMID 17526579.

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[refGRCh38Ensembl-1] ENSG00000256870 GRCh38: Ensembl release 89: ENSG00000262217, ENSG00000256870 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020062 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12107270-5] Rodriguez AM, Perron B, Lacroix L, Caillou B, Leblanc G, Schlumberger M, Bidart JM, Pourcher T (Jul 2002). "Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes". J Clin Endocrinol Metab. 87 (7): 3500–3. doi:10.1210/jc.87.7.3500. PMID 12107270.

[pmid12829793-6] Li H, Myeroff L, Smiraglia D, Romero MF, Pretlow TP, Kasturi L, Lutterbaugh J, Rerko RM, Casey G, Issa JP, Willis J, Willson JK, Plass C, Markowitz SD (Jul 2003). "SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers". Proc Natl Acad Sci U S A. 100 (14): 8412–7. doi:10.1073/pnas.1430846100. PMC 166243. PMID 12829793.

[entrez-7] "Entrez Gene: SLC5A8 solute carrier family 5 (iodide transporter), member 8".

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@@ Line 16: / Line 16: @@
 *{{cite journal   |vauthors=Hong C, Maunakea A, Jun P, etal |title=Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8 |journal=Cancer Res. |volume=65 |issue= 9 |pages= 3617–23 |year= 2005 |pmid= 15867356 |doi= 10.1158/0008-5472.CAN-05-0048 |doi-access= free }}
 *{{cite journal   |vauthors=Paroder V, Spencer SR, Paroder M, etal |title=Na+/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: Molecular characterization of SMCT |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 19 |pages= 7270–5 |year= 2006 |pmid= 16670197 |doi= 10.1073/pnas.0602365103  | pmc=1456061 }}
-*{{cite journal   |vauthors=Hu S, Liu D, Tufano RP, etal |title=Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer |journal=Int. J. Cancer |volume=119 |issue= 10 |pages= 2322–9 |year= 2006 |pmid= 16858683 |doi= 10.1002/ijc.22110 }}
+*{{cite journal   |vauthors=Hu S, Liu D, Tufano RP, etal |title=Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer |journal=Int. J. Cancer |volume=119 |issue= 10 |pages= 2322–9 |year= 2006 |pmid= 16858683 |doi= 10.1002/ijc.22110 |s2cid=45869283 }}
-*{{cite journal   |vauthors=Gopal E, Miyauchi S, Martin PM, etal |title=Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract |journal=Pharm. Res. |volume=24 |issue= 3 |pages= 575–84 |year= 2007 |pmid= 17245649 |doi= 10.1007/s11095-006-9176-1 }}
+*{{cite journal   |vauthors=Gopal E, Miyauchi S, Martin PM, etal |title=Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract |journal=Pharm. Res. |volume=24 |issue= 3 |pages= 575–84 |year= 2007 |pmid= 17245649 |doi= 10.1007/s11095-006-9176-1 |s2cid=11325302 }}
 *{{cite journal   |vauthors=Coady MJ, Wallendorff B, Bourgeois F, etal |title=Establishing a Definitive Stoichiometry for the Na+/Monocarboxylate Cotransporter SMCT1 |journal=Biophys. J. |volume=93 |issue= 7 |pages= 2325–31 |year= 2007 |pmid= 17526579 |doi= 10.1529/biophysj.107.108555  | pmc=1965447 }}
 {{refend}}

Sodium-coupled monocarboxylate transporter 1: Difference between revisions

Revision as of 01:06, 13 October 2020

See also

References

Further reading