Zinc transporter ZIP1: Difference between revisions
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'''Zinc transporter ZIP1''' is a [[protein]] that in humans is encoded by the ''SLC39A1'' [[gene]].<ref name="pmid10610721">{{cite journal | vauthors = Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J | title = Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex | journal = Genomics | volume = 62 | issue = 2 | pages = 272–80 |date=Feb 2000 | pmid = 10610721 |
'''Zinc transporter ZIP1''' is a [[protein]] that in humans is encoded by the ''SLC39A1'' [[gene]].<ref name="pmid10610721">{{cite journal | vauthors = Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J | title = Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex | journal = Genomics | volume = 62 | issue = 2 | pages = 272–80 |date=Feb 2000 | pmid = 10610721 | doi = 10.1006/geno.1999.5993 }}</ref><ref name="pmid10681536">{{cite journal | vauthors = Gaither LA, Eide DJ | title = Functional expression of the human hZIP2 zinc transporter | journal = J Biol Chem | volume = 275 | issue = 8 | pages = 5560–4 |date=Mar 2000 | pmid = 10681536 | doi =10.1074/jbc.275.8.5560 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27173}}</ref> |
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The protein ZIP1 is responsible for the active transport of [[zinc]] into [[prostate]] cells. In many [[prostate cancer]]s SLC39A1 is silenced causing prostate cancer cells to be low in zinc.<ref name="pmid16700911">{{cite journal | vauthors = Costello LC, Franklin RB | title = The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots | journal = Mol. Cancer | volume = 5 |
The protein ZIP1 is responsible for the active transport of [[zinc]] into [[prostate]] cells. In many [[prostate cancer]]s SLC39A1 is silenced causing prostate cancer cells to be low in zinc.<ref name="pmid16700911">{{cite journal | vauthors = Costello LC, Franklin RB | title = The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots | journal = Mol. Cancer | volume = 5 | pages = 17 | year = 2006 | pmid = 16700911 | pmc = 1481516 | doi = 10.1186/1476-4598-5-17 }}</ref> |
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==See also== |
==See also== |
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*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }} |
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }} |
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*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} |
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} |
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*{{cite journal |vauthors=Franklin RB, Feng P, Milon B, etal |title=hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer |journal=Mol. Cancer |volume=4 |
*{{cite journal |vauthors=Franklin RB, Feng P, Milon B, etal |title=hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer |journal=Mol. Cancer |volume=4 |pages= 32 |year= 2006 |pmid= 16153295 |doi= 10.1186/1476-4598-4-32 | pmc=1243239 }} |
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*{{cite journal |vauthors=Tang Z, Sahu SN, Khadeer MA, etal |title=Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells |journal=Bone |volume=38 |issue= 2 |pages= 181–98 |year= 2006 |pmid= 16203195 |doi= 10.1016/j.bone.2005.08.010 }} |
*{{cite journal |vauthors=Tang Z, Sahu SN, Khadeer MA, etal |title=Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells |journal=Bone |volume=38 |issue= 2 |pages= 181–98 |year= 2006 |pmid= 16203195 |doi= 10.1016/j.bone.2005.08.010 }} |
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*{{cite journal |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 |doi-access= free }} |
*{{cite journal |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 |doi-access= free }} |
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Revision as of 13:12, 5 December 2020
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| Aliases | SLC39A1, ZIP1, ZIRTL, solute carrier family 39 member 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 604740; MGI: 1353474; HomoloGene: 40906; GeneCards: SLC39A1; OMA:SLC39A1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.[5][6][7]
The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.[8]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000143570 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052310 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.
- ^ Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.
- ^ "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".
- ^ Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
Further reading
- Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
- Gaither LA, Eide DJ (2001). "The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells". J. Biol. Chem. 276 (25): 22258–64. doi:10.1074/jbc.M101772200. PMID 11301334.
- Milon B, Dhermy D, Pountney D, et al. (2001). "Differential subcellular localization of hZip1 in adherent and non-adherent cells". FEBS Lett. 507 (3): 241–6. doi:10.1016/S0014-5793(01)02950-7. PMID 11696349.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Franklin RB, Ma J, Zou J, et al. (2003). "Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells". J. Inorg. Biochem. 96 (2–3): 435–42. doi:10.1016/S0162-0134(03)00249-6. PMC 4465841. PMID 12888280.
- Dufner-Beattie J, Langmade SJ, Wang F, et al. (2004). "Structure, function, and regulation of a subfamily of mouse zinc transporter genes". J. Biol. Chem. 278 (50): 50142–50. doi:10.1074/jbc.M304163200. PMID 14525987.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Franklin RB, Feng P, Milon B, et al. (2006). "hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer". Mol. Cancer. 4: 32. doi:10.1186/1476-4598-4-32. PMC 1243239. PMID 16153295.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - Tang Z, Sahu SN, Khadeer MA, et al. (2006). "Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells". Bone. 38 (2): 181–98. doi:10.1016/j.bone.2005.08.010. PMID 16203195.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Huang L, Kirschke CP (2007). "A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein". FEBS J. 274 (15): 3986–97. doi:10.1111/j.1742-4658.2007.05933.x. PMID 17635580.
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