Anion exchange protein 2
Template:PBB Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene.[1][2] AE2 is functionally similar to the Band 3 Cl-/HCO3- exchange protein.
Mice have been used to explore the function of AE2. AE2 contributes to basolateral membrane HCO3- transport in the gastrointestinal tract.[3] AE3 is required for spermiogenesis in mice.[4] AE2 is required for normal osteoclast function.[5][6] The activity of AE2 is sensitive to pH.[7]
AE3 has been suggested as a target for prevention of diabetic vasculopathy.[8]
See also
References
- ^ Tanner MJ (1993). "Molecular and cellular biology of the erythrocyte anion exchanger (AE1)". Semin Hematol. 30 (1): 34–57. PMID 8434259.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ "Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)".
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.