Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1gene.[5][6][7]
The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.[8]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID10610721.
^Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID10681536.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Gaither LA, Eide DJ (2001). "The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells". J. Biol. Chem. 276 (25): 22258–64. doi:10.1074/jbc.M101772200. PMID11301334.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Milon B, Dhermy D, Pountney D, et al. (2001). "Differential subcellular localization of hZip1 in adherent and non-adherent cells". FEBS Lett. 507 (3): 241–6. doi:10.1016/S0014-5793(01)02950-7. PMID11696349.
Dufner-Beattie J, Langmade SJ, Wang F, et al. (2004). "Structure, function, and regulation of a subfamily of mouse zinc transporter genes". J. Biol. Chem. 278 (50): 50142–50. doi:10.1074/jbc.M304163200. PMID14525987.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Tang Z, Sahu SN, Khadeer MA, et al. (2006). "Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells". Bone. 38 (2): 181–98. doi:10.1016/j.bone.2005.08.010. PMID16203195.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID16303743.
Huang L, Kirschke CP (2007). "A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein". FEBS J. 274 (15): 3986–97. doi:10.1111/j.1742-4658.2007.05933.x. PMID17635580.