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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{PBB|geneid=6527}}
{{Infobox_gene}}
The '''low affinity sodium-glucose cotransporter''' also known as the '''sodium/glucose cotransporter 3''' (SGLT3) or '''solute carrier family 5 member 4''' (SLC5A4) is a [[protein]] that in humans is encoded by the ''SLC5A4'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6527| accessdate = }}</ref><ref name="pmid9501190">{{cite journal | author = Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H | title = Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 6 | pages = 2914–9 | year = 1998 | month = March | pmid = 9501190 | pmc = 19669 | doi = | url = | issn = }}</ref><ref name="pmid12354616">{{cite journal | author = Jung H | title = The sodium/substrate symporter family: structural and functional features | journal = FEBS Lett. | volume = 529 | issue = 1 | pages = 73–7 | year = 2002 | month = October | pmid = 12354616 | doi = | url = | issn = }}</ref>
The '''low affinity sodium-glucose cotransporter''' also known as the '''sodium/glucose cotransporter 3''' (SGLT3) or '''solute carrier family 5 member 4''' (SLC5A4) is a [[protein]] that in humans is encoded by the ''SLC5A4'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6527}}</ref><ref name="pmid9501190">{{cite journal | vauthors = Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H | title = Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 6 | pages = 2914–9 | date = March 1998 | pmid = 9501190 | pmc = 19669 | doi = 10.1073/pnas.95.6.2914 | bibcode = 1998PNAS...95.2914V | doi-access = free }}</ref><ref name="pmid12354616">{{cite journal | vauthors = Jung H | title = The sodium/substrate symporter family: structural and functional features | journal = FEBS Letters | volume = 529 | issue = 1 | pages = 73–7 | date = October 2002 | pmid = 12354616 | doi = 10.1016/S0014-5793(02)03184-8 | doi-access = free }}</ref> It functions as a sugar sensor.


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal | author = Munafò MR, Clark TG, Roberts KH, Johnstone EC | title = Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression | journal = Neuropsychobiology | volume = 53 | issue = 1 | pages = 1–8 | year = 2006 | pmid = 16319503 | doi = 10.1159/000089915 | url = | issn = }}
* {{cite journal | vauthors = Munafò MR, Clark TG, Roberts KH, Johnstone EC | title = Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression | journal = Neuropsychobiology | volume = 53 | issue = 1 | pages = 1–8 | year = 2006 | pmid = 16319503 | doi = 10.1159/000089915 | s2cid = 12803994 }}
*{{cite journal |author=Blaya C, Salum GA, Lima MS, ''et al.'' |title=Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis. |journal=Behavioral and Brain Functions |volume=3 |issue= |pages= 41 |year= 2007 |pmid= 17705872 |doi= 10.1186/1744-9081-3-41 }}
* {{cite journal | vauthors = Blaya C, Salum GA, Lima MS, Leistner-Segal S, Manfro GG | title = Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis | journal = Behavioral and Brain Functions | volume = 3 | pages = 41 | year = 2007 | pmid = 17705872 | pmc = 1994953 | doi = 10.1186/1744-9081-3-41 | doi-access = free }}
*{{cite journal |author=Diez-Sampedro A, Hirayama BA, Osswald C, ''et al.'' |title=A glucose sensor hiding in a family of transporters. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 20 |pages= 11753–8 |year= 2003 |pmid= 13130073 |doi= 10.1073/pnas.1733027100 }}
* {{cite journal | vauthors = Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H | title = A glucose sensor hiding in a family of transporters | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 20 | pages = 11753–8 | date = September 2003 | pmid = 13130073 | pmc = 208830 | doi = 10.1073/pnas.1733027100 | bibcode = 2003PNAS..10011753D | doi-access = free }}
*{{cite journal |author=Fairchild TJ |title=Protection of muscle membrane excitability during cycling in humans: a role for SGLT3? |journal=J. Appl. Physiol. |volume=104 |issue= 1 |pages= 315; author reply 316 |year= 2008 |pmid= 18198291 |doi= 10.1152/japplphysiol.00793.2007 }}
* {{cite journal | vauthors = Fairchild TJ | title = Protection of muscle membrane excitability during cycling in humans: a role for SGLT3? | journal = Journal of Applied Physiology | volume = 104 | issue = 1 | pages = 315; author reply 316 | date = January 2008 | pmid = 18198291 | doi = 10.1152/japplphysiol.00793.2007 | s2cid = 29443314 }}
*{{cite journal |author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
* {{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | date = December 1999 | pmid = 10591208 | doi = 10.1038/990031 | bibcode = 1999Natur.402..489D | doi-access = free }}
*{{cite journal | author = Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM | title = Imino sugars are potent agonists of the human glucose sensor SGLT3 | journal = Mol. Pharmacol. | volume = 71 | issue = 2 | pages = 628–34 | year = 2007 | month = February | pmid = 17110502 | doi = 10.1124/mol.106.030288 | url = | issn = }}
* {{cite journal | vauthors = Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM | title = Imino sugars are potent agonists of the human glucose sensor SGLT3 | journal = Molecular Pharmacology | volume = 71 | issue = 2 | pages = 628–34 | date = February 2007 | pmid = 17110502 | doi = 10.1124/mol.106.030288 | s2cid = 13642065 }}
{{refend}}
{{refend}}


{{Solute carrier family|bg|bg0}}
{{Membrane transport proteins}}


[[Category:Solute carrier family]]
[[Category:Solute carrier family]]

Latest revision as of 01:25, 3 December 2023

SLC5A4
Identifiers
AliasesSLC5A4, DJ90G24.4, SAAT1, SGLT3, solute carrier family 5 member 4
External IDsMGI: 1927848 HomoloGene: 8591 GeneCards: SLC5A4
Orthologs
SpeciesHumanMouse
Entrez

6527

64452

Ensembl

ENSG00000100191

ENSMUSG00000020229

UniProt

Q9NY91

Q9ET37

RefSeq (mRNA)

NM_014227

NM_133184

RefSeq (protein)

NP_055042

NP_573447

Location (UCSC)Chr 22: 32.22 – 32.26 MbChr 10: 75.98 – 76.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The low affinity sodium-glucose cotransporter also known as the sodium/glucose cotransporter 3 (SGLT3) or solute carrier family 5 member 4 (SLC5A4) is a protein that in humans is encoded by the SLC5A4 gene.[5][6][7] It functions as a sugar sensor.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100191 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020229 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter)".
  6. ^ Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H (March 1998). "Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1". Proceedings of the National Academy of Sciences of the United States of America. 95 (6): 2914–9. Bibcode:1998PNAS...95.2914V. doi:10.1073/pnas.95.6.2914. PMC 19669. PMID 9501190.
  7. ^ Jung H (October 2002). "The sodium/substrate symporter family: structural and functional features". FEBS Letters. 529 (1): 73–7. doi:10.1016/S0014-5793(02)03184-8. PMID 12354616.

Further reading[edit]


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