β-defensin 2
| β-defensin | ||
|---|---|---|
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| according to PDB 1E4Q | ||
| other names |
Beta-defensin 2, BD-2, hBD-2, Beta-defensin 4A, DEFB4A, DEFB-2, DEFB102, DEFB2, DEFB4, HBD-2, SAP1, |
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| Properties of human protein | ||
| Mass / length primary structure | 64 amino acids , 7,038 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 1673 | |
| Ensemble | ENSG00000171711 | |
| UniProt | O15263 | |
| Refseq (mRNA) | NM_004942.3 | |
| Refseq (protein) | NP_004933.1 | |
| PubMed search |
1673
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β-Defensin 2 is a protein from the group of defensins .
properties
As a defensin, β-defensin is an antimicrobial peptide that is increasingly formed in the course of the immune response . β-Defensin is produced by neutrophils and epithelial cells in the skin and in the airways . It has an antibacterial effect against Candida and Gram-negative bacteria. β-Defensin binds to CCR6 and triggers chemotaxis in the CCR6-bearing cells . Below a concentration of 2.4 mM it is present as a monomer .
Web links
Individual evidence
- ↑ J. Harder, J. Bartels, E. Christophers, JM Schröder: A peptide antibiotic from human skin. In: Nature. Volume 387, Number 6636, June 1997, p. 861, doi : 10.1038 / 43088 , PMID 9202117 .
- ↑ JM Schröder, J. Harder: Human beta-defensin-2. In: The international journal of biochemistry & cell biology. Volume 31, Number 6, June 1999, pp. 645-651, PMID 10404637 .
- ↑ MV Sawai, HP Jia, L. Liu, V. Aseyev, JM Wiencek, PB McCray, T. Ganz, WR Kearney, BF Tack: The NMR structure of human beta-defensin-2 reveals a novel alpha-helical segment. In: Biochemistry. Volume 40, Number 13, April 2001, pp. 3810-3816, PMID 11300761 .