3-methoxy-4-hydroxyphenyl glycol

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Structural formula
Structural formula of 3-methoxy-4-hydroxyphenylglycol
Structural formula without specifying the stereochemistry
General
Non-proprietary name 3-methoxy-4-hydroxyphenyl glycol
other names
  • 1- (4-Hydroxy-3-methoxyphenyl) ethane-1,2-diol ( IUPAC )
  • MHPG
  • MOPEG
Molecular formula C 9 H 12 O 4
Brief description

colorless solid

External identifiers / databases
CAS number
  • 534-82-7
  • 67423-45-4 (Hemi piperazin iumsalz)
PubChem 10805
ChemSpider 10348
Wikidata Q223097
properties
Molar mass 184.19 g · mol -1
Physical state

firmly

Melting point

115-119 ° C

safety instructions
GHS labeling of hazardous substances
07 - Warning

Caution

H and P phrases H: 315-319-335
P: 261-305 + 351 + 338
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

3-Methoxy-4-hydroxyphenylglycol ( MHPG , MOPEG ) is a metabolite of the metanephrines , which are the direct breakdown products of the catecholamines adrenaline and noradrenaline . In the brain, it is the primary metabolite of norepinephrine. It is released into the blood and liquor , so an increase may be a sign of previous activity of the sympathetic nervous system .

Low blood and cerebrospinal fluid levels are associated with anorexia nervosa .

Individual evidence

  1. ↑ a b c d Data sheet 4-Hydroxy-3-methoxyphenylglycol hemipiperazinium salt from Sigma-Aldrich , accessed on November 5, 2016 ( PDF ).
  2. ↑ Kanda T, Azuma K, Sakai F, Tazaki Y. Department of Internal Medicine, School of Medicine, Kitasato University, Sagamihara, Japan .: Increase in cerebrospinal fluid and plasma levels of 3-methoxy-4-hydroxyphenylglycol in acute stroke. . In: Stroke . 22, No. 12, 1991, pp. 1525-1529. PMID 1962327 .
  3. ↑ Biederman J, Herzog DB, Rivinus TM, Ferber RA, Harper GP, Orsulak PJ, Harmatz JS, Schildkraut JJ: Urinary mhpg in anorexia nervosa patients with and without a concomitant major depressive disorder. . In: J Psychiatr Res. . 18, No. 2, 1984, pp. 149-160. PMID 6747913 .