5-hydroxyuracil
Structural formula | |||||||||||||||||||
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General | |||||||||||||||||||
Surname | 5-hydroxyuracil | ||||||||||||||||||
other names |
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Molecular formula | C 4 H 4 N 2 O 3 | ||||||||||||||||||
Brief description |
beige solid |
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properties | |||||||||||||||||||
Molar mass | 128.09 g mol −1 | ||||||||||||||||||
Physical state |
firmly |
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Melting point |
> 300 ° C |
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solubility |
little in DMSO and methanol |
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safety instructions | |||||||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
5-Hydroxyuracil is a heterocyclic organic compound with a pyrimidine backbone. It is a derivative of the nucleobase uracil with an additional hydroxyl group in position 5.
Extraction and presentation
Both 5-hydroxyuracil and 5-hydroxyuridine can be prepared from the corresponding 5-bromopyrimidines ( 5-bromouracil ) by mild basic hydrolysis .
Individual evidence
- ↑ a b c d e data sheet 2,4,5-trihydroxypyrimidine, 98% from AlfaAesar, accessed on March 9, 2019 ( PDF )(JavaScript required) .
- ↑ Erich Schiller: Free Radicals and Inhalation Pathology Respiratory System, Mononuclear Phagocyte System, Hypoxia and Reoxygenation, Pneumoconioses, and Other Granulomatoses Cancer . Springer Science & Business Media, 2004, ISBN 978-3-540-00201-7 , pp. 710 ( limited preview in Google Book search).
- ^ GP Ellis, GB West: Progress in Medicinal Chemistry . Butterworth-Heinemann, 2011, ISBN 978-0-08-086256-9 , pp. 62 ( limited preview in Google Book search).