Adenylosuccinate synthase

Adenylosuccinate synthase
	Ribbon model of the ADS dimer from common wheat ( Triticum aestivum ), according to PDB 1DJ3
	Existing structural data : 2GJO
Properties of human protein
Mass / length primary structure	456/7 amino acids
Secondary to quaternary structure	Homodimer
Cofactor	Mg 2+
Isoforms	2 gene copies ( ADSS , ADSSL ) in liver, muscles
Identifier
Gene name	ADS
External IDs	OMIM : 612498 ; UniProt : Q8N142 ;
Enzyme classification
EC, category	6.3.4.4 , ligase
Response type	shortcut
Substrate	GTP + IMP + aspartate
Products	Adenylosuccinate + P i + GDP
Occurrence
Parent taxon	Creature

The adenylosuccinate synthase (after IUBMB also: IMP-aspartate ligase ) is the enzyme that the linking of IMP and aspartate to adenylosuccinate catalyzed . This reaction is part of the de novo synthesis of AMP ( metabolism of purines ) in all living things. In humans, as in all vertebrates , there are two isoforms , localized in the muscles and the liver , which are encoded by the ADSS and ADSSL genes located on chromosomes 1 and 14 .

Catalyzed reaction

+ + GTP + GDP + P _i ${\ displaystyle \ longrightarrow}$
${\ displaystyle \ longrightarrow}$

IMP and aspartate are ligated using GTP.

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