Ajmalicin

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Structural formula
Structural formula of (-) - ajmalicin
General
Surname Ajmalicin
other names
  • Predatory basin
  • 19 α -Methyl-18-oxa-16,17-didehydro-yohimban-16-carboxylic acid methyl ester
Molecular formula C 21 H 24 N 2 O 3
External identifiers / databases
CAS number 483-04-5
EC number 207-589-5
ECHA InfoCard 100.006.900
PubChem 441975
Wikidata Q412957
Drug information
ATC code

C04 AX39 , C04 BA03

properties
Molar mass 352.43 g mol −1
Physical state

firmly

Melting point

258 ° C

solubility

bad in water

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
07 - Warning

Caution

H and P phrases H: 302
P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Ajmalicin , more precisely (-) - Ajmalicin (synonym: Raubasin ), is an indole alkaloid from the roots of the Indian snake root ( Rauvolfia serpentina ).

Indian snake root ( Rauwolfia serpentina )

Pharmacological properties

Ajmalicin is an α1-adrenoceptor antagonist and, like reserpine, promotes peripheral blood flow, but without reducing blood pressure. It also has an anti-emetic effect. It is used medicinally in the adjuvant treatment of disorders of the peripheral arterial blood supply. Overdose can cause hypotension , tachycardia , dizziness, sweating, excitement, sedation and allergic skin reactions. Ajmalicin is of almost no therapeutic importance. In Germany, no monopreparations with this active ingredient are approved.

See also

Individual evidence

  1. ↑ a b DIMDI : ATC Classification Germany, 2019
  2. ↑ a b c d data sheet ajmalicin (PDF) from Carl Roth , accessed on February 5, 2013.
  3. ↑ E. Teuscher: Biogenic Medicines. 5th edition. Wissenschaftliche Verlagsgesellschaft, 1997. ISBN 3-8047-1482-X . P. 342.
  4. ↑ a b Summary of Product Characteristics: Lamuran , as of June 2005. Laboratorio Farmaceutico SIT Specialità Igienico Terapeutiche Srl (Italy)