Alan R. Saltiel
Alan Robert Saltiel (born November 29, 1953 in New Brunswick , New Jersey ) is an American biochemist who mainly deals with diabetes mellitus and the insulin system.
Saltiel graduated from Duke University ( Bachelor Accounts 1975) and in 1980 at the University of North Carolina doctorate in biochemistry. He was then a researcher at the pharmaceutical company Burroughs-Wellcome (with Pedro Cuatrecasas ) until 1984 and assistant professor at Rockefeller University from 1984 to 1990 . From 1990 to 1996 he was Head of Signal Transduction at the Parke-Davis Pharmaceutical Research Division of Warner-Lambert and from 1996 to 2000 Head of Cell Biology. Since 2001 he has been director of the University of Michigan Life Sciences Institute and professor at the University of Michigan Medical School.
He investigated the immediate mechanisms of the cell reaction and signaling pathways after the docking of insulin, but also EGF and nerve growth factor to the cell. He is particularly interested in possible malfunctions in the insulin signaling pathway that can trigger diabetes. For example, in addition to the PI-3 kinase signaling pathway, he and his group discovered another one via the SH2 adapter protein APS (see insulin receptor ). They also identified various G proteins (TC 10) involved in the signaling pathway .
He investigated the role of special macrophages in adipose tissue (adipose tissue macrophages, ATM) as a possible mechanism for the development of diabetes in overweight (adiposis), based on the idea that obesity causes a state of latent inflammation (at a low level) in the body.
Saltiel received the American Diabetes Association's Rosalyn Yalow Research and Development Award and the 1990 John J. Abel Award . He has been married since 1981 and has three children.
Fonts
- with CR Kahn Insulin signaling and the regulation of glucose and lipid metabolism , Nature, Volume 414, 2001, pp. 799-806
Web links
Individual evidence
- ↑ Life and career data according to American Men and Women of Science , Thopmson Gale 2004
| personal data | |
|---|---|
| SURNAME | Saltiel, Alan R. |
| ALTERNATIVE NAMES | Saltiel, Alan Robert |
| BRIEF DESCRIPTION | American biochemist |
| DATE OF BIRTH | November 29, 1953 |
| PLACE OF BIRTH | New Brunswick , New Jersey |