Amine fluorides

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As amine fluorides are hydrofluoride of amines referred. The substance group designation “amine fluoride” is common, but chemically incorrect.

Amine fluorides, which are used in dental care and medicine, are cationic surfactants . They have a long, hydrophobic alkyl group and a polar, hydrophilic protonated amine with a fluoride as an anion .


Amine fluorides are mainly used as an active ingredient for plaque prophylaxis in toothpaste or mouthwash. The effect is based on its surfactant-like structure and its fluorine content. They only accumulate slightly on tooth surfaces, which is enough to reduce tooth decay. The exact mode of action is the subject of current research.

Amine fluorides inhibit bacterial growth. The amine is responsible for the inhibition. Since they penetrate the cell membrane very easily compared to inorganic fluorides , they also reach effective concentrations there much faster.



Structural formula of ethanolamine · HF (ethanolamine · hydrofluoride).

The first toothpaste with amine fluoride was developed and patented in Germany in 1951/52 and came onto the market under the trade name "Biox Fluor" ( Knoll AG , Ludwigshafen). It contained ethanolamine hydrofluoride as the active ingredient . The production of the active ingredient is based on a patent from Knoll AG, inventor was Kurt Kraft. Oskar Eichler , toxicologist at the University of Heidelberg , was co-owner of the corresponding toothpaste patent (1951) together with Kraft. GABA only launched similar products a few years later .

See also


Web links

Individual evidence

  1. Thomas Faidt, Andreas Friedrichs, Samuel Grandthyll, Christian Spengler, Karin Jacobs: Effect of Fluoride Treatment on the Acid Resistance of Hydroxyapatite . In: Langmuir . tape 34 , no. 50 , December 18, 2018, p. 15253-15258 , doi : 10.1021 / acs.langmuir.8b03412 .
  2. Caries protection: Fluoride protects differently than expected. In: Spiegel Online . December 17, 2010, accessed December 10, 2015 .
  3. Frank Müller, Christian Zeitz, Hubert Mantz, Karl-Heinz Ehses, Flavio Soldera, Jörg Schmauch, Matthias Hannig, Stefan Hüfner, Karin Jacobs: Elemental Depth Profiling of Fluoridated Hydroxyapatite: Saving Your Dentition by the Skin of Your Teeth? In: Langmuir . Volume 26, No. 24, 2010, pp. 18750-18759. doi: 10.1021 / la102325e .
  4. Frederic Meyer, Joachim Enax: The oral cavity as an ecosystem . In: Biology in Our Time . tape 48 , no. 1 , 2018, p. 62–68 , doi : 10.1002 / biuz.201810641 .
  5. ^ Relation between surface activity and antibacterial activity of amine-fluorides . In: International Journal of Pharmaceutics . tape 131 , no. 1 , April 5, 1996, pp. 33-39 , doi : 10.1016 / 0378-5173 (95) 04299-7 .
  6. Biox-Fluor at the Regensburg Archive for Advertising Research, accessed on November 14, 2012.
  7. German Patent Office: Patent DE971375. Patented in Germany on August 26, 1951.
  8. German Dental Journal. Volume 7, 1952, pp. 702 & 708.
  9. T. Imfeld: 40 years of amine fluoride. In: Switzerland. Mschr. Zahnmed. Volume 114, No. 3, 2004, p. 259.