Olaflur
Structural formula | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
General | ||||||||||||||||
Non-proprietary name | Olaflur | |||||||||||||||
other names |
|
|||||||||||||||
Molecular formula | C 27 H 60 F 2 N 2 O 3 | |||||||||||||||
External identifiers / databases | ||||||||||||||||
|
||||||||||||||||
Drug information | ||||||||||||||||
ATC code | ||||||||||||||||
Drug class |
Caries prophylactic |
|||||||||||||||
properties | ||||||||||||||||
Molar mass | 498.78 g mol −1 | |||||||||||||||
Physical state |
firmly |
|||||||||||||||
safety instructions | ||||||||||||||||
|
||||||||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Olaflur ( INN ) is an active ingredient that is used locally for the prophylaxis of dental caries and periodontitis .
Chemically, it is the dihydrofluoride of a long-chain tertiary diamine . Olaflur belongs to the amine fluoride group .
use
Olaflur has been used for the prevention of tooth decay and periodontitis since 1966. Concentrations of 500 ppm for children's toothpaste and 1250 ppm for “adults” toothpaste (calculated as fluoride) are sufficient . The average daily dose is (eng. Defined daily dose , DDD) 1.1 mg (calculated as fluoride).
toxicology
Fluorides are poisonous if used incorrectly. In the event of a permanent overdose, they can be stored in the bones and change their properties. Overdosing in the first few years of life, before the permanent teeth are developed, can lead to dental fluorosis , which is a localized discoloration and weakening of the hard tissue of the teeth. In Germany, dental care medicines containing amine fluoride require a prescription, with the exception of gels in pack sizes of up to 25 g, provided that the packaging states that their use is restricted to adults and children from the age of 6 and to a single dose per week which corresponds to a fluoride content of up to 7 mg.
Trade names
Aminomed (D), Elmex (D, A, CH), Friscodent / Eurodont Multicare (D)
Individual evidence
- ↑ Entry on OLAFLUR in the CosIng database of the EU Commission, accessed on March 21, 2020.
- ↑ harmonized classification for this substance . A labeling of Olaflur in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), which was accessed on May 6, 2017, is reproduced from a self-classification by the distributor . There is not yet a
- ↑ Hans-Jürgen Gülzow and Claas Sudbrake: A modern active ingredient: 40 years of caries protection with amine fluoride ( Memento from June 15, 2012 in the Internet Archive ). Dental notices. 15/2003, p. 32.
- ↑ Rüdiger Blume: How acids endanger teeth and what you can do about them .
- ↑ ATC / DDD-Index: Olaflur , accessed on May 6, 2017.