Anna Seelig-Löffler

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Anna Seelig-Löffler, 2011

Anna Magdalena Seelig-Löffler (born October 7, 1944 ) is a Swiss biochemist and structural biologist .

Life

Anna Seelig-Löffler studied human medicine and chemistry and received her doctorate in 1973 at the Institute for Physical Chemistry at the University of Basel . She then did research as a postdoctoral fellow with Joachim Seelig and later as an independent scientist at the Biozentrum of the University of Basel in the Department of Biophysical Chemistry . In 1992 Anna Seelig-Löffler completed her habilitation in biochemistry and was later appointed adjunct professor for biophysical chemistry. In 2012 she retired .

Act

Anna Seelig-Löffler examines the functionality of cell membranes and their components. She is particularly interested in membrane proteins , so-called ABC transporters , which prevent a wide variety of substances from entering the cell . Using microphysiometry, she was able to track the transport of drugs from the cell membrane in real time . She discovered a universal substrate pattern for P-glycoprotein . This makes it possible to estimate how strongly a substance binds to the transporter and how great it is to reach the site of action. On this basis, she developed a model to predict drug uptake at biological membranes.

Awards

2008 STK Award from the Swiss Society for Thermal Analysis and Calorimetry

Publications (selection)

Complete list of publications

  • A. Seelig, J. Seelig: The dynamic structure of fatty acyl chains in a phospholipid bilayer measured by deuterium magnetic resonance . In: Biochemistry , 13, 1974, pp. 4839-4845, PMID 4371820
  • A. Seelig: A general pattern for substrate recognition by P-glycoprotein . In: Eur J Biochem , 251, 1998, pp. 252-261, PMID 9492291
  • G. Gerebtzoff, A. Seelig: In silico prediction of blood-brain barrier permeation using the calculated molecular cross-sectional area as main parameter . In: J Chem Inf Model , 46, 2006, pp. 2638-2650, PMID 17125204
  • A. Seelig: The role of size and charge for blood-brain barrier permeation of drugs and fatty acids . In: J Mol Neurosci , 33, 2007, pp. 32-41, PMID 17901543
  • X. Li-Blatter, A. Seelig: Exploring the P-glycoprotein binding cavity with polyoxyethylene alkyl ethers . In: Biophys J , 99, 2010, pp. 3589-3598, PMID 21112283

Web links

Individual evidence

  1. ↑ Emeriti. Biozentrum Basel, accessed on March 25, 2014
  2. ↑ STK Awards, Swiss Society for Thermal Analysis and Calorimetry at stk-online.ch, accessed on March 25, 2014.
  3. ↑ List of publications , accessed on March 25, 2014.
personal data
SURNAME Seelig-Löffler, Anna
ALTERNATIVE NAMES Seelig, Anna Magdalena
BRIEF DESCRIPTION Swiss biochemist and structural biologist
DATE OF BIRTH October 7, 1944