Annette Beck-Sickinger

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Annette Gabriele Beck-Sickinger (born October 28, 1960 in Aalen ) is a German chemist and biologist . Since 1999 she has held a full professorship for biochemistry and bioorganic chemistry at the University of Leipzig .

life and career

Beck-Sickinger studied chemistry and biology at the University of Tübingen , where she did her doctorate in 1989 under Günther Jung . After completing his doctorate, there followed several research stays, including in the USA and Denmark . After a post-doctorate in Zurich , she completed her habilitation in 1995, also in Tübingen. 1996–1999 she was appointed assistant professor for pharmaceutical biochemistry at the ETH Zurich. In 1999, she accepted a call to the University of Leipzig, where she was elected to the University Council in 2010. In 2009 she was a visiting professor at Vanderbilt University in Nashville / TN.

She has been a full member of the Saxon Academy of Sciences since 2009 and of the German Academy of Sciences Leopoldina (chemistry section) since 2012 . She is president of the Society for Biochemistry and Molecular Biology .

Beck-Sickinger was a board member of the Society of German Chemists from 2004 to 2012 . From 2008 to 2010 she was also its vice-president. From 2012 to 2018 she was a member of the Science Council .

Her research activities include the ligand-receptor interactions of neuropeptides, signal transduction and the chemical modification of proteins. She is the author of several textbooks on biochemistry and has published numerous publications.

Beck-Sickinger has received numerous prizes and awards, such as the Leonidas Zervas Award from the European Peptide Society , the gold medal from the Max Bergmann Society, the Leipzig Science Award and the Saxon Order of Merit . For 2018 she was awarded the Albrecht Kossel Prize of the Society of German Chemists .

criticism

In March 2015, a rejection of a male Indian applicant in connection with an alleged reference to the rape problem in Indian society was controversial. After screenshots of the letter of rejection circulated on the Internet , the German ambassador to India, Michael Steiner, wrote a letter to Beck-Sickinger in which he criticized the way in which it was rejected and pointed out that India was not a country of rapists. Beck-Sickinger had already rejected another Indian applicant the year before on the same grounds, but without causing a stir. In her apology to the University of Leipzig, Beck-Sickinger stated that the e-mails quoted were part of a longer conversation about social conditions in Germany and India. The published e-mails were then cut from this e-mail conversation. In fact, she turned the student away because her laboratories were full. Two Indian students are currently visiting her as part of a laboratory internship.

After the university had not published the e-mail traffic for data protection reasons, at least the rector of the university, Beate Schücking , and the student council were given access to the e-mails. Both independently came to the conclusion that the email published by the Indian student was a forgery and that the student's rejection was not related to problems in Indian society. The subsequent email discussion came about after a provocation by the Indian student.

Works and publications (selection)

Books

  • with Peter JA Weber: Combinatorial Methods in Chemistry and Biology. Spectrum Publishing House. 1999, ISBN 3-8274-0157-7 .
  • with Peter Weber: Combinatorial strategies in biology and chemistry. Wiley, Chichester, England New York 2002, ISBN 0-471-49727-4 .
  • with Ulrich Hahn (Ed.): Textbook of Biochemistry. Wiley, 2002, ISBN 3-527-30519-X . (German translation by: Donald Voet, Judith G. Voet, Charlotte W. Pratt: Principles in Biochemistry. )
  • with Stefan Bräse: Combinatorial chemistry on solid supports. Springer, Berlin / New York 2007, ISBN 978-3-540-72509-1 .
  • with Matthias Petzold: Paradigm Evolution. Peter Lang Verlag, Stuttgart 2009, ISBN 978-3-631-56082-2 .

Publications in magazines

  • Z. Yang, S. Han, M. Keller, A. Kaiser, BJ Bender, M. Bosse, K. Burkert, LM Kögler, D. Wifling, G. Bernhardt, N. Plank, T. Littmann, P. Schmidt, C. Yi, B. Li, S. Ye, R. Zhang, B. Xu, D. Larhammar, RC Stevens, D. Huster, J. Meiler, Q. Zhao, Beck-Sickinger AG, A. Buschauer, B. Wu: Structural basis of ligand binding modes at the neuropeptide YY (1) receptor. In: Nature. 556 (7702), Apr 2018, pp. 520-524.
  • L. Wanka, S. Babilon, A. Kaiser, K. Mörl, Beck-Sickinger AG: Different mode of arrestin-3 binding at the human Y (1) and Y (2) receptor. Cell signal. 50, Oct 2018, pp. 58-71.
  • A. Kaiser, C. Hempel, L. Wanka, M. Schubert, HE Hamm, Beck-Sickinger AG: G Protein Preassembly Rescues Efficacy of W (6.48) Toggle Mutations in Neuropeptide Y (2) Receptor. In: Mol Pharmacol. 93 (4), Apr 2018, pp. 387-401.
  • J. Lotze, P. Wolf, U. Reinhardt, O. Seitz, K. Mörl, Beck-Sickinger AG: Time-Resolved Tracking of Separately Internalized Neuropeptide Y (2) Receptors by Two-Color Pulse-Chase. In: ACS Chem Biol. 13 (3), Mar 16, 2018, pp. 618-627.
  • M. Schubert, J. Stichel, Y. Du, IR Tough, G. Sliwoski, J. Meiler, HM Cox, CD Weaver, Beck-Sickinger AG: Identification and Characterization of the First Selective Y (4) Receptor Positive Allosteric Modulator. In: J Med Chem. 60 (17), Sep 14, 2017, pp. 7605-7612.
  • D. Böhme, J. Krieghoff, Beck-Sickinger AG: Double Methotrexate-Modified Neuropeptide Y Analogues Express Increased Toxicity and Overcome Drug Resistance in Breast Cancer Cells. In: J Med Chem. 59 (7), Apr 14, 2016, pp. 3409-3417.
  • S. Zernia, F. Ott, K. Bellmann-Sickert, R. Frank, M. Klenner, HG Jahnke, A. Prager, B. Abel, A. Robitzki, Beck-Sickinger AG: Peptide-Mediated Specific Immobilization of Catalytically Active Cytochrome P450 BM3 Variant. In: Bioconjug Chem. 27 (4), Apr 20, 2016, pp. 1090-1097.
  • M. Pagel, R. Hassert, T. John, K. Braun, M. Wießler, B. Abel, Beck-Sickinger AG: Multifunctional Coating Improves Cell Adhesion on Titanium by using Cooperatively Acting Peptides. In: Angew Chem Int Ed Engl. 55 (15), Apr 4, 2016, pp. 4826-4830.
  • VM Ahrens, KB Kostelnik, R. Rennert, D. Böhme, S. Kalkhof, D. Kosel, L. Weber, M. von Bergen, Beck-Sickinger AG: A cleavable cytolysin-neuropeptide Y bioconjugate enables specific drug delivery and demonstrates intracellular mode of action. In: J Control Release. 209, Jul 10, 2015, pp. 170-178.
  • A. Kaiser, P. Müller, T. Zellmann, HA Scheidt, L. Thomas, M. Bosse, R. Meier, J. Meiler, D. Huster, Beck-Sickinger AG, P. Schmidt: Unwinding of the C-Terminal Residues of neuropeptide Y is critical for Y₂ receptor binding and activation. In: Angew Chem Int Ed Engl. 54 (25), Jun 15, 2015, pp. 7446-7449.

Web links

Individual evidence

  1. ↑ Homepage of Annette Beck-Sickinger Working Group Biochemistry and Bioorganic Chemistry, University of Leipzig, accessed on June 13, 2020
  2. ↑ Member entry by Prof. Dr. Annette Beck-Sickinger (with picture and CV) at the German Academy of Natural Scientists Leopoldina , accessed on June 29, 2016.
  3. ↑ Board of Directors and Advisory Board of the Society for Biochemistry and Molecular Biology from the Society's website accessed on April 26, 2019
  4. ^ GDCh: Two female chemists in the Science Council (online) , accessed on January 22, 2013.
  5. ^ The European Peptide Society (EPS): list of the award winners , accessed on January 22, 2013.
  6. ↑ Do not give an internship to Indian students. from: www.welt.de , March 9, 2015, accessed December 29, 2017.
  7. ↑ German Professor Apologises For 'Rape Problem' Email To Indian Student. In: Huffingtonpost. July 15, 2015, accessed December 29, 2017.
  8. ↑ Not the first time German prof rejected Indian student. mumbaimirror.com, March 10, 2015.
  9. ↑ Professor Beck-Sickinger apologizes for statements. ( Memento of April 2, 2015 in the Internet Archive ) Press release of the University of Leipzig of March 9, 2015, accessed on December 29, 2017.
  10. ↑ An obviously falsified email has been published. ( Memento from June 12, 2015 in the Internet Archive ) Press release of the University of Leipzig from March 12, 2015, accessed on December 29, 2017.
  11. ^ Statement in the Beck-Sickinger case of the Student Council of the University of Leipzig from April 2, 2015, accessed on December 29, 2017.
personal data
SURNAME Beck-Sickinger, Annette
ALTERNATIVE NAMES Beck-Sickinger, Annette Gabriele (full name); Beck-Sickinger, Annette G.
BRIEF DESCRIPTION German chemist and biologist
DATE OF BIRTH October 28, 1960
PLACE OF BIRTH Bask