Anthony GE Pearse

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Anthony "Tony" Guy Everson Pearse , often quoted AGE Pearse, (born August 9, 1916 in Kent , † May 24, 2003 in South Molton , Devon (England) ) was a British physician (histochemistry).

Pearse was the son of an army officer and studied medicine at Trinity College, Cambridge University and St. Bartholomew's Hospital, University of London, specializing in pathology. During World War II he served as a surgeon in the Royal Navy. He then worked in the Morbid Anatomy Department of the Royal Postgraduate Medical School at Hammersmith Hospital in London. He was a professor there from 1965 (on the first chair for histochemistry) and stayed there until his retirement in 1981.

Pearse was known for studying chemical substances (fats, proteins, carbohydrates, nucleic acids, enzymes, etc.) in human tissue (histochemistry) and their pathology. He also developed devices such as a cryostat (Pearse-Slee cryostat) and devices for freeze-drying. In 1969 he proposed the APUD concept, with the hypothesis of the common embryological and evolutionary origin of nerve cells and endocrine cells that produce peptide hormones. In 1966 he had previously discovered a common feature of these endocrine cells, which also led to their naming by Pearse: they took up precursors of biologically active amino acids, converted them through decarboxylation and stored the product in vesicles and then secreted the peptide hormones formed from them.

1972 to 1974 he was President of the Royal Microscopical Society. In 1973 Pearse was made a member of the German Academy of Sciences Leopoldina , with the Schleiden Medal he was awarded in 1989. In 1979 he received the Ernst Jung Prize .

Fonts

  • Histochemistry - theoretical and applied , 1953, 4th edition in three volumes, Churchill Livingstone 1980, 1985, 1991 (also translated into Polish, Russian and Spanish)

literature

  • Susan Van Noorden Professor AGE Pearse (1916-2003): A tribute , The Histochemical Journal, Volume 34, 2002, pp. 617-619, pdf

Individual evidence

  1. ^ Pearse The cytochemistry and infrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept , In: Journal of Histochemistry and Cytochemistry , Volume 17, 1969, pp. 303-313, abstract
  2. ↑ See also CAR Boyd Amine uptake and peptide hormone secretion: APUD cells in a new landscape , In: The Journal of Physiology , Volume 531, 2001, p. 581, abstract
  3. ↑ Pearse 5-hydroxytryptophan uptake by dog ​​thyroid 'C' cells, and its possible significance in polypeptide hormone production , In: Nature , Volume 211, 1966, 598-600
  4. ↑ APUD for amine precursor uptake and decarboxylation
personal data
SURNAME Pearse, Anthony GE
ALTERNATIVE NAMES Pearse, Anthony Guy Everson
BRIEF DESCRIPTION British medic
DATE OF BIRTH August 9, 1916
PLACE OF BIRTH Kent , England , United Kingdom of Great Britain and Ireland
DATE OF DEATH May 24, 2003
Place of death South Molton , Devon , England , UK