Aryl formamidase

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Aryl formamidase
Properties of human protein
Mass / length primary structure 308 amino acids
Identifier
Gene name AFMID
External IDs
Enzyme classification
EC, category 3.5.1.9 hydrolase
Response type Spin-off from formate
Substrate N-formylkynurenine + H 2 O
Products Kynurenine + formate
Occurrence
Homology family Aryl formamidase
Parent taxon Euteleostomi

In the arylformamidase (KF) is the enzyme that the second part of step, decomposition of the amino acid tryptophan , namely the elimination of formate of N-formylkynurenine catalyzed . The enzyme is found in vertebrates . In humans it is produced in all types of tissue.

Mice without KF show problems with the kidneys and the immune system, but can partially break down N-formylkynurenine. This means that there is likely another enzyme catalyzing this reaction.

The AFMID - gene coding for the arylformamidase encoded , is the rare example of a gene whose expression inversely with the acetylation of histone in the promoter correlated.

Catalyzed reaction

N-formyl-L-kynurenine+ H 2 O   + HCOO -  L-kynurenine

Formic acid is split off from N -formyl- L- kynurenine by hydrolysis and L- kynurenine is formed.

Individual evidence

  1. UniProt Q63HM1
  2. BioGPS entry
  3. Dobrovolsky VN, Bowyer JF, Pabarcus MK, et al : Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype . In: Biochim. Biophys. Acta . 1724, No. 1-2, June 2005, pp. 163-72. doi : 10.1016 / j.bbagen.2005.03.010 . PMID 15866519 .
  4. Schuettengruber B, Doetzlhofer A, Kroboth K, Wintersberger E, Seiser C: Alternate activation of two divergently transcribed mouse genes from a bidirectional promoter is linked to changes in histone modification . In: J. Biol. Chem. . 278, No. 3, January 2003, pp. 1784-93. doi : 10.1074 / jbc.M204843200 . PMID 12411446 .

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