Aryl formamidase
Aryl formamidase | ||
---|---|---|
Properties of human protein | ||
Mass / length primary structure | 308 amino acids | |
Identifier | ||
Gene name | AFMID | |
External IDs | ||
Enzyme classification | ||
EC, category | 3.5.1.9 , hydrolase | |
Response type | Spin-off from formate | |
Substrate | N-formylkynurenine + H 2 O | |
Products | Kynurenine + formate | |
Occurrence | ||
Homology family | Aryl formamidase | |
Parent taxon | Euteleostomi |
In the arylformamidase (KF) is the enzyme that the second part of step, decomposition of the amino acid tryptophan , namely the elimination of formate of N-formylkynurenine catalyzed . The enzyme is found in vertebrates . In humans it is produced in all types of tissue.
Mice without KF show problems with the kidneys and the immune system, but can partially break down N-formylkynurenine. This means that there is likely another enzyme catalyzing this reaction.
The AFMID - gene coding for the arylformamidase encoded , is the rare example of a gene whose expression inversely with the acetylation of histone in the promoter correlated.
Catalyzed reaction
Formic acid is split off from N -formyl- L- kynurenine by hydrolysis and L- kynurenine is formed.
Individual evidence
- ↑ UniProt Q63HM1
- ↑ BioGPS entry
- ↑ Dobrovolsky VN, Bowyer JF, Pabarcus MK, et al : Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype . In: Biochim. Biophys. Acta . 1724, No. 1-2, June 2005, pp. 163-72. doi : 10.1016 / j.bbagen.2005.03.010 . PMID 15866519 .
- ↑ Schuettengruber B, Doetzlhofer A, Kroboth K, Wintersberger E, Seiser C: Alternate activation of two divergently transcribed mouse genes from a bidirectional promoter is linked to changes in histone modification . In: J. Biol. Chem. . 278, No. 3, January 2003, pp. 1784-93. doi : 10.1074 / jbc.M204843200 . PMID 12411446 .
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Tryptophan Metabolism - Learning and Teaching Materials