Bialaphos

Structural formula
General
Surname	Bialaphos
other names	Bilanafos L -alanyl- L -alanyl-phosphinothricin
Molecular formula	C 11 H 22 N 3 O 6 P
External identifiers / databases
CAS number 35597-43-4 EC number 609-147-0 ECHA InfoCard 100.113.731 PubChem 5462314 ChemSpider 4575372 Wikidata Q855280
properties
Molar mass	323.28 g mol −1
safety instructions
GHS labeling of hazardous substances Caution H and P phrases H: 302-315-319-335 P: ?
Toxicological data	500 mg kg −1 ( LD 50 ,  mouse ,  oral )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Bialaphos ( L -alanyl- L -alanyl-phosphinothricin) is a natural tripeptide consisting of the amino acids alanine and glufosinate . Bialaphos was isolated as the product of two different soil-dwelling streptomycetes ( Streptomyces hygroscopicus and Streptomyces viridochromogenes ). Bialaphos has herbicidal properties that go back to the biologically active phosphinothricin group.

literature

• Takeshi Murakami, Hiroyuki Anzai, Satoshi Imai, Atsuyuki Satoh, Kozo Nagaoka, Charles J. Thompson: The bialaphos biosynthetic genes of Streptomyces hygroscopicus: Molecular cloning and characterization of the gene cluster. In: MGG Molecular & General Genetics. 205, 1986, p. 42, doi : 10.1007 / BF02428031 .
• Stephen O. Duke, Franck E. Dayan: Modes of Action of Microbially-Produced Phytotoxins. In: Toxins. 3, 2011, p. 1038, doi : 10.3390 / toxins3081038 .

Individual evidence

1. ↑ There is not yet a harmonized classification for this substance . A labeling of L-2-Amino-4 - [(hydroxy) (methyl) phosphinoyl] buthyryl-L-alanyl-L-alanine in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA) is reproduced, which is derived from a self-classification by the distributor on July 10, 2019.
2. ↑ Entry on Bialaphos in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on July 10, 2019.