Bombesin
| Bombesin ( bombina bombina ) | ||
|---|---|---|
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| Structural formula | ||
| Mass / length primary structure | 14 amino acids | |
| Identifier | ||
| External IDs | ||
Bombesin is a peptide hormone isolated from the skin of the fire-bellied toad ( Bombina bombina ) for the first time in 1971 , which consists of 14 amino acids and can also be detected in humans and mammals in a similar structure as gastrin releasing peptide (GRP) with 27 amino acids.
Primary structure
Primary structure: Pyr - Gln - Arg - Leu - Gly - Asn - Gln - Trp - Ala - Val - Gly - His - Leu - Met - CONH 2 . (Modifications: N-terminus: glutamine → pyroglutamic acid, C-terminus: methionine → methionine amide) (Pyr for pyroglutamic acid is also abbreviated as pGlu)
Nine of the last ten amino acids at the C-terminal end match in bombesin and GRP and represent the biologically active part of the substance and at the same time the shortest fragment that can bind to the GRP receptor . With Neuromedin B, both belong to the bombesin-like peptides family .
The Chinese fire-bellied toad ( Bombina orientalis ) has at least three different forms of bombesin, all agonists with different affinities for the well-known bombesin receptors. Bombesin was found in the skin of Bombina variegata along with other insulinotropic peptides.
outlook
Since tumor cells increasingly have neuropeptide-specific receptors and bombesin has also been shown to be involved in the development of breast and prostate cancer , research is currently being carried out into metabolically more stable bombesin analogues that are radioactively labeled both in diagnostics and - as radiopharmaceuticals - for targeted therapy of various types Malignancies could be used.
In addition, it has been shown that despite its stimulating effect on gastrin and gastric acid production, bombesin could be a substance with gastric protective properties.
swell
- ↑ UniProt P84214
- ↑ Three different forms of bombesin (PDF; 339 kB)
- ↑ Bombesin and completely new insilonotropic substances in the skin of Bombina variegata (English) doi : 10.1515 / BC.2004.027
- ↑ PMC 1360124 (free full text).