COL27A1
| Collagen type XXVII, alpha 1 | ||
|---|---|---|
| other names |
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| Properties of human protein | ||
| Mass / length primary structure | 1,860 amino acids , 186,892 Da | |
| Isoforms | 3 | |
| Identifier | ||
| Gene names | COL27A1; KIAA1870; STLS | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Euteleostomi | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 85301 | 373864 |
| Ensemble | ENSG00000196739 | ENSMUSG00000045672 |
| UniProt | Q8IZC6 | Q5QNQ9 |
| Refseq (mRNA) | NM_032161 | NM_025685 |
| Refseq (protein) | NP_116277.2 | NP_079961.3 |
| Gene locus | Chr 9: 114.16 - 114.31 Mb | Chr 4: 63.21 - 63.33 Mb |
| PubMed search | 85301 |
373864
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Collagen type XXVII, alpha 1 is a collagen that the gene COL27A1 encoded is. It forms homotrimers , which in turn form type XXVII collagen fibrils .
properties
Collagen type XXVII, alpha 1 is located in the basement membrane of the keratinocytes in hemidesmosomes type I, which essentially functions as an adhesion molecule and surface receptor in multilayered epithelia .
The accumulation of collagen type XVII, alpha 1 in melanocytic tumors is associated with malignant transformation . Thus it is a potential biomarker for malignancy and is also a target for antibody-induced apoptosis of melanomas .
Collagen XVII is mostly in the tissue in the eye and the ear expressed and participates in the development of the skeleton. It forms structural elements in the extracellular matrix of the tissue, skin and tendon. Type XXVII, alpha 1 collagen plays an important role in cartilage calcification and osteogenesis . By the interaction of human chondrocytes - cell line C28 / I2 GDF6 is gene expression increased from COL26A1. The transcription factor SOX9 is responsible for the transcriptional activation of COL27A1.
Web links
Individual evidence
- ↑ Jyri M. Moilanen, Nina Kokkonen, Stefanie Löffek, Juha P. Väyrynen, Erkki Syväniemi, Tiina Hurskainen, Markus Mäkinen, Kai Klintrup, Jyrki Mäkelä, Raija Sormunen, et al .: Collagen XVII expression correlates with the invasion and metastasis of colorectal cancer . In: Hum Pathol . 46, No. 3, March 2015, pp. 434–442. doi : 10.1016 / j.humpath.2014.11.020 . PMID 25623077 .
- ↑ T. Krenacs, G. Kiszner, E. Stelkovics, P. Balla, I. Teleki, I. Nemeth, E. Varga, I. Korom, T. Barbai, V. Plotar, et al .: Collagen XVII is expressed in malignant but not in benign melanocytic tumors and it can mediate antibody induced melanoma apoptosis . In: Histochem Cell Biol . 138, No. 4, October 2012, pp. 653-667. doi : 10.1007 / s00418-012-0981-9 . PMID 22688676 .
- ↑ Raymond P. Boot-Handford, Danny S. Tuckwell, Darren A. Plumb, Claire Farrington Rock, Richard Poulsom: A novel and highly conserved collagen (pro (alpha) 1 (XXVII)) with a unique expression pattern and unusual molecular characteristics establishes a new clade within the vertebrate fibrillar collagen family . In: J Biol Chem . 278, No. 33, August 15, 2003, pp. 31067-31077. doi : 10.1074 / jbc.M212889200 . PMID 12766169 .
- ↑ FY Zhou, AQ Wei, B. Shen, L. Williams, ADDiwan: Cartilage Derived Morphogenetic Protein-2 Induces Cell Migration and Its Chondrogenic Potential in C28 / I2 Cells . In: Int J Spine Surg . 9, No. 52, October 22, 2015. doi : 10.14444 / 2052 . PMID 26609507 . PMC 4657611 (free full text).
- ↑ Elizabeth Jenkins, Jennie B. Moss, James M. Pace, Laura C. Bridgewater: The new collagen gene COL27A1 contains SOX9-responsive enhancer elements . In: Matrix Biol . 24, No. 3, May 2005, pp. 177-184. doi : 10.1016 / j.matbio.2005.02.004 . PMID 15922909 . PMC 3205994 (free full text).