Ceftolozane
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Non-proprietary name | Ceftolozane | |||||||||||||||
other names |
(6 R , 7 R ) -3 - [(5-Amino-4 - {[(2-aminoethyl) carbamoyl] amino} -1-methyl-1 H -pyrazol-2-ium-2-yl) methyl] - 7 - [(2 Z ) -2- (5-amino-1,2,4-thiadiazol-3-yl) -2 - {[(2-carboxypropan-2-yl) oxy] imino} acetamido] -8- oxo-5-thia-1-azabicyclo [4.2.0] oct-2-en-2-carboxylate ( IUPAC ) |
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Molecular formula | C 23 H 30 N 12 O 8 S 2 | |||||||||||||||
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Molar mass | 666.69 g · mol -1 | |||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Ceftolozane is an antibiotic from the group of cephalosporins . The bactericidal effect is, as with other β-lactam antibiotics by inhibiting bacterial cell wall synthesis.
Ceftolozane is approved in combination with the β-lactamase inhibitor tazobactam for the treatment of hospital-acquired pneumonia as well as complicated urinary tract infections , acute pyelonephritis and complicated intra-abdominal infections (trade name Zerbaxa ). The combination with tazobactam serves to protect against degradation of ceftolozane by β-lactamases . Ceftolozane can only be administered parenterally .
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ Specialist information ZERBAXA, as of August 2019. Accessed on February 12, 2020 .
- ↑ Avoxa ?? Mediengruppe Deutscher Apotheker GmbH: Pharmaceutical newspaper online - Drugs: Ceftolozane (Zerbaxa® / 2015). In: www.pharmazeutische-zeitung.de. Retrieved December 22, 2016 .
Information on the grouping of parenteral cephalosporins can be found at https://www.awmf.org/uploads/tx_szleitlinien/082-006l_S2k_Parenterale_Antibiotika_2019-08.pdf Accessed February 12, 2020