Ceftolozane

from Wikipedia, the free encyclopedia
Structural formula
Structure of Ceftolozane
General
Non-proprietary name Ceftolozane
other names

(6 R , 7 R ) -3 - [(5-Amino-4 - {[(2-aminoethyl) carbamoyl] amino} -1-methyl-1 H -pyrazol-2-ium-2-yl) methyl] - 7 - [(2 Z ) -2- (5-amino-1,2,4-thiadiazol-3-yl) -2 - {[(2-carboxypropan-2-yl) oxy] imino} acetamido] -8- oxo-5-thia-1-azabicyclo [4.2.0] oct-2-en-2-carboxylate ( IUPAC )

Molecular formula C 23 H 30 N 12 O 8 S 2
External identifiers / databases
CAS number
  • 689293-68-3 (ceftolozane)
  • 936111-69-2 (ceftolozane sulfalt )
PubChem 53234134
ChemSpider 25999973
DrugBank DB09050
Wikidata Q21011231
Drug information
ATC code

J01 DI54

Drug class
Mechanism of action

Inhibition of cell wall synthesis

properties
Molar mass 666.69 g · mol -1
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Ceftolozane is an antibiotic from the group of cephalosporins . The bactericidal effect is, as with other β-lactam antibiotics by inhibiting bacterial cell wall synthesis.

Ceftolozane is approved in combination with the β-lactamase inhibitor tazobactam for the treatment of hospital-acquired pneumonia as well as complicated urinary tract infections , acute pyelonephritis and complicated intra-abdominal infections (trade name Zerbaxa ). The combination with tazobactam serves to protect against degradation of ceftolozane by β-lactamases . Ceftolozane can only be administered parenterally .

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ↑ Specialist information ZERBAXA, as of August 2019. Accessed on February 12, 2020 .
  3. ↑ Avoxa ?? Mediengruppe Deutscher Apotheker GmbH: Pharmaceutical newspaper online - Drugs: Ceftolozane (Zerbaxa® / 2015). In: www.pharmazeutische-zeitung.de. Retrieved December 22, 2016 .

Information on the grouping of parenteral cephalosporins can be found at https://www.awmf.org/uploads/tx_szleitlinien/082-006l_S2k_Parenterale_Antibiotika_2019-08.pdf Accessed February 12, 2020