Tazobactam
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Non-proprietary name | Tazobactam | |||||||||||||||||||||
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Melting point |
> 170 ° C (tazobactam sodium, decomposition) |
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pK s value |
2.1 |
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solubility |
Water: 50 g l −1 , (tazobactam sodium, clear, colorless solution) |
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Toxicological data | ||||||||||||||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Tazobactam is a drug from the group of β-lactamase inhibitors . Tazobactam is only slightly antimicrobial, but broadens the antibiotic spectrum of the β-lactam antibiotic piperacillin . It is therefore only used in a fixed combination with piperacillin.
Both substances are not effective orally and are therefore administered parenterally .
pharmacology
The β-lactamase inhibitors have a similar chemical structure to β-lactam antibiotics and contain the β-lactam ring. By combining the β-lactamase- labile piperacillin with the β-lactamase inhibitor tazobactam, the antibiotic resistance of bacteria against β-lactamase-labile penicillins can be overcome. Tazobactam has hardly any direct antibacterial activity. It binds irreversibly to the clinically common enzyme β-lactamase, which is produced by some bacteria , and thus prevents the inactivation of the β-lactam antibiotics . Most plasmid-mediated penicillinases are inhibited, less or not at all the chromosomally mediated cephalosporinases .
Chemical-pharmaceutical information
The water-soluble sodium salt of tazobactam is used medicinally.
Varia
The combination of piperacillin / tazobactam is not recommended for perioperative prophylaxis.
Trade names
Piperacillin / Tazobactam (D, A, CH), Pipitaz (A), Tazobac (D, CH), Tazonam (A)
literature
- Hermann J. Roth: Medicinal Chemistry: Targets and Drugs; 157 tables . German Apotheker-Verlag, Stuttgart 2005, ISBN 3-7692-3483-9 .
Individual evidence
- ↑ a b Entry on tazobactam. In: Römpp Online . Georg Thieme Verlag, accessed on May 1, 2014.
- ↑ a b c data sheet Tazobactam sodium salt from Sigma-Aldrich , accessed on October 23, 2016 ( PDF ).
- ↑ a b Entry on tazobactam in the ChemIDplus database of the United States National Library of Medicine (NLM) .
- ↑ Jörg Braun: Infectious Diseases. In: Jörg Braun, Roland Preuss (Ed.): Clinic Guide Intensive Care Medicine. 9th edition. Elsevier, Munich 2016, ISBN 978-3-437-23763-8 , pp. 437-519, here: pp. 485 f. ( Piperacillin / tazobactam ).