Cereblon
| Cereblon | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 50.5 kilodaltons / 442 amino acids (isoform 1)
50.5 kilodaltons / 441 amino acids (isoform 2) |
|
| Isoforms | 2 | |
| Identifier | ||
| Gene name | CRBN | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Multicellular animals | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 51185 | 58799 |
| Ensemble | ENSG00000113851 | ENSMUSG00000005362 |
| UniProt | Q96SW2 | Q8C7D2 |
| Refseq (mRNA) | NM_001173482 | NM_021449 |
| Refseq (protein) | NP_001166953 | NP_067424 |
| Gene locus | Chr 3: 3.15 - 3.18 Mb | Chr 6: 106.78 - 106.8 Mb |
| PubMed search | 51185 |
58799
|
Cereblon is a protein found in all animals . In humans, it is expressed in many types of tissue , but most of all in the brain . There it stabilizes certain potassium channels in the cell membrane and thus contributes to learning and the function of memory . Cereblon has another function during embryonic development , where it forms the substrate-binding subunit of a ubiquitin ligase , which regulates transcription and influences the growth of limbs. The medicinal substance thalidomide binds to Cereblon and probably disrupts the normal growth of the embryo ( thalidomide scandal ). Mutations in CRBN - gene can be inherited mild dementia lead due to learning and memory disorders.
Individual evidence
Web links
- VB Gerritsen / Protein Spotlight: a short story