Daidzein

Structural formula
General
Surname	Daidzein
other names	Daidzein Daidzeol 4 ', 7-dihydroxyisoflavone 7,4'-dihydroxyisoflavone 7-Hydroxy-3- (4-hydroxyphenyl) -4 H -1-benzopyran-4-one
Molecular formula	C 15 H 10 O 4
Brief description	pale yellowish solid
External identifiers / databases
CAS number 486-66-8 EC number 207-635-4 ECHA InfoCard 100.006.942 PubChem 5281708 ChemSpider 4445025 DrugBank DB13182 Wikidata Q408732
properties
Molar mass	254.24 g mol −1
Physical state	firmly
Melting point	290 ° C
safety instructions
GHS labeling of hazardous substances Caution H and P phrases H: 315-319 P: 305 + 351 + 338
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Daidzein (from Japanese daidzu outdated for daizu ( 大豆 ), "soybean") belongs to the group of natural isoflavones .

Soybean ( Glycine max ), ripe pods

Isoflavones such as daidzein and genistein are found in a number of plants, but primarily in soybeans and soy products such as tofu and soy meat. Soy isoflavones are a group of compounds found both in and in isolation from soybeans.

There is several evidence that daidzein, like another isoflavone ( genistein ), shuts down transcription of the enzyme catechol- O- methyltransferase (COMT), which normally breaks down estradiol .

Individual evidence

1. ↑ ^{a b} Datasheet Daidzein (PDF) from Calbiochem, accessed on December 8, 2015.
2. ↑ ^{a b} Datasheet Daidzein at Sigma-Aldrich , accessed on March 24, 2011 ( PDF ).
3. ^ A. Senning: Elsevier's Dictionary of Chemoetymology . Elsevier, Amsterdam 2007, ISBN 978-0-444-52239-9 , pp. 105 ( limited preview in Google Book search).
4. ↑ Lehmann L, Jiang L, Wagner J: Soy isoflavones decrease the catechol-O-methyltransferase-mediated inactivation of 4-hydroxyestradiol in cultured MCF-7 cells . In: Carcinogenesis . 29, No. 2, February 2008, pp. 363-370. doi : 10.1093 / carcin / bgm235 . PMID 18192686 .