Dermcidin
| Dermcidin DCD-1L | ||
|---|---|---|
|
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| Ribbon / rod model according to PDB 2KSG | ||
| Properties of human protein | ||
| Mass / length primary structure | 48 amino acids | |
| Precursor | Dermcidin (110 amino acids) | |
| Identifier | ||
| Gene name | DCD | |
| External IDs | ||
Dermcidins (DCD) are peptides that are produced in human sweat glands . One derivative is Dermcidin DCD-1L , an antimicrobial peptide. Thus it is also a natural antibiotic .
Dermcidin DCD-1L, which is produced in sweat from a dermcidin precursor by proteolytic cleavage, is distributed on the surface of the skin with the sweat, remains stable in the protective acid mantle of the skin and has amphiphilic properties. It is a broad spectrum antibiotic and acts in a broad pH spectrum against many known germs such as E. coli bacteria ( Escherichia coli ), the yeast Candida albicans and staphylococci and other Gram-negative or Gram-positive bacteria. During the interaction with bacterial membranes DCD-1L form oligomeric complexes that by zinc - ion be stabilized.
Individual evidence
- ↑ Schittek B, Hipfel R, Sauer B, et al. : Dermcidin: a novel human antibiotic peptide secreted by sweat glands . In: Nature Immunology . 2, No. 12, December 2001, pp. 1133-1137. PMID 11694882 . Retrieved June 13, 2010.
- ↑ Sylvia Feil: Marked Defense: Antimicrobial Sweat . In: Chemistry in Our Time . tape 46 , no. 3 , 2012, p. 135 , doi : 10.1002 / ciuz.201290031 .