Dexibuprofen

Structural formula
General
Non-proprietary name	Dexibuprofen
other names	(+) - (2 S ) -2- [4- (2-methylpropyl) phenyl] propanoic acid; ( S ) -2- [4- (2-methylpropyl) phenyl] propanoic acid; (+) - 2- [4- (2-Methylpropyl) phenyl] propanoic acid; (+) - (2 S ) -2- [4- (2-methylpropyl) phenyl] propionic acid; ( S ) -2- [4- (2-methylpropyl) phenyl] propionic acid; (+) - 2- [4- (2-methylpropyl) phenyl] propionic acid;
Molecular formula	C 13 H 18 O 2
Brief description	white crystals
External identifiers / databases
EC number	610-620-9
ECHA InfoCard	100.106.960
PubChem	39912
ChemSpider	36498
DrugBank	DB09213
Wikidata	Q420051
Drug information
ATC code	M01 AE14
Drug class	non-steroidal anti-inflammatory drug
properties
Molar mass	206.28 g mol −1
Physical state	firmly
Melting point	49-53 ° C
solubility	almost insoluble in water
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances	no GHS pictograms
	no GHS pictograms
H and P phrases	H: no H-phrases
	P: no P-phrases
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Dexibuprofen is the ( S ) - enantiomer of the racemate ibuprofen , which was first patented in 1996. Dexibuprofen's like Ibuprofen, a cyclooxygenase - inhibitor , which as a drug ( non-steroidal anti ) is used.

Since it is supposed to be about twice as effective, you get by with a smaller amount of drug per tablet. In addition, the effect of this pain reliever sets in a little faster than the racemate ibuprofen.

Since the body's own 2-arylpropionyl-CoA-epimerase can racemize dexibuprofen to ibuprofen, the therapeutic advantages of dexibuprofen over ibuprofen are controversial. Dexibuprofen is said to cause fewer side effects, but this is also doubted by other studies.

Trade names

Monopreparations

Deltaran (D), DexOptifen (CH), Dolomagon (D), Eu-Med neu (A), Monactil (A), Movone (A), Seractil (A, CH), Atriscal (A), as well as a generic (A )

Individual evidence

↑ ^a ^b ^c Data sheet dexibuprofen at Acros, accessed on February 20, 2010.
↑ Data sheet (S) - (+) - Ibuprofen from Sigma-Aldrich , accessed on March 24, 2011 ( PDF ).
^ Paul F. White (2003): Can the Use of Specific Isomers Improve the Safety and Efficacy of Nonsteroidal Antiinflammatory Drugs? In: Anesth Analg. 97 (2): pp. 309-310; PMID 12873909 .
^ Dexibuprofen , in: Pharmazeutische Zeitung Online , GOVI-Verlag.
↑ Seractil forte 400 mg - Instructions for use. Medicamio, accessed on March 10, 2017 (Austrian German).

[Acros-1] Data sheet dexibuprofen at Acros, accessed on February 20, 2010.

[Sigma-2] Data sheet (S) - (+) - Ibuprofen from Sigma-Aldrich , accessed on March 24, 2011 ( PDF ).

[3] Paul F. White (2003): Can the Use of Specific Isomers Improve the Safety and Efficacy of Nonsteroidal Antiinflammatory Drugs? In: Anesth Analg. 97 (2): pp. 309-310; PMID 12873909 .

[4] Dexibuprofen , in: Pharmazeutische Zeitung Online , GOVI-Verlag.

[5] Seractil forte 400 mg - Instructions for use. Medicamio, accessed on March 10, 2017 (Austrian German).