Elbasvir
Structural formula | ||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
![]() |
||||||||||||||||||||||
General | ||||||||||||||||||||||
Surname | Elbasvir | |||||||||||||||||||||
other names |
|
|||||||||||||||||||||
Molecular formula | C 49 H 55 N 9 O 7 | |||||||||||||||||||||
External identifiers / databases | ||||||||||||||||||||||
|
||||||||||||||||||||||
properties | ||||||||||||||||||||||
Molar mass | 882.015 g mol −1 | |||||||||||||||||||||
safety instructions | ||||||||||||||||||||||
|
||||||||||||||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Elbasvir is a medicinal and antiviral drug used to treat infections with the hepatitis C virus .
properties
Elbasvir belongs to a group of NS5A inhibitors . It binds to the non-structural protein 5A of the hepatitis C virus of genotypes 1 and 4, as well as daclatasvir , samatasvir , ledipasvir , MK-8408 , odalasvir , ombitasvir , ravidasvir and velpatasvir . Elbasvir is administered orally at 50 mg as a combination preparation with the NS3 / 4A inhibitor grazoprevir at 100 mg. The drug approval of the combination preparation for the genotypes HCV1 and HCV4 took place in 2016 in the USA. This was followed by approvals for Canada, Switzerland and the European Union (July 22, 2016).
Trade names
- Zepatier ( MSD Sharp & Dohme )
Individual evidence
- ↑ a b Sigma-Aldrich / Advanced ChemBlocks: Elbasvir - ADV947321183 , accessed on October 13, 2017
- ↑ M. El Kassas, T. Elbaz, Y. Abd El Latif, G. Esmat: Elbasvir and grazoprevir for chronic hepatitis C genotypes 1 and 4. In: Expert review of clinical pharmacology. Volume 9, Number 11, November 2016, pp. 1413-1421, doi: 10.1080 / 17512433.2016.1233813 , PMID 27603877 .
- ↑ FDA approves Zepatier for treatment of chronic hepatitis C genotypes 1 and 4 . January 28, 2016.
- ↑ European Medicines Agency - Find medicine - Zepatier. Retrieved December 16, 2017 .