Elizabeth C. Miller

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Elizabeth Cavert Miller ( May 2, 1920 in Minneapolis , Minnesota , † October 14, 1987 ) was an American biochemist , known for fundamental research on the chemical mechanism of carcinogenesis , where she worked closely with her husband James A. Miller worked together.

Miller was the daughter of an economist at the Federal Land Bank in Minneapolis. She studied biochemistry at the University of Minnesota (Bachelor in 1941, Master in 1943). In 1945 she received her doctorate from Carl Baumann. As a post-doctoral student, she was at the McArdle Laboratory for Cancer Research at the University of Wisconsin – Madison , where she and her husband (since 1942) James A. Miller worked on chemical carcinogenesis. From 1973 to 1987 she was Associate Director of the McArdle Laboratory. She was also Professor of Oncology at the University of Wisconsin-Madison. She died of kidney cancer.

In 1947, the Millers discovered that an azo dye could cause cancer by binding to proteins in the rat liver. In 1949 they showed that the ability of a substance cancer can be influenced by the action of another chemical, which affects the processing in the metabolism, and in 1960 they showed the existence of metabolic products that were more carcinogens than the starting material. These discoveries had implications for other areas of toxicology. After discovering the exact genetic role of DNA around 1953, the Millers were able to demonstrate the carcinogenic effects of many chemicals as a result of their interaction with DNA. After showing in the 1960s that chemical carcinogens could be detected through increased mutation rates, they investigated the carcinogenic ability of a number of substances found in the environment, industrial chemicals and food.

Elizabeth Miller was the editor of the American Association for Cancer Research (AACR) journal Cancer Research from 1954 to 1964 . From 1976 to 1977 she was President of the AACR. From 1978 to 1980 she was on the Council (Cancer Panel) of the National Cancer Institute . In 1978 she became a member of the National Academy of Sciences , and in 1981 she was admitted to the American Academy of Arts and Sciences .

In 1980 she and James A. Miller received the Charles S. Mott Prize for cancer research and both received numerous other prizes, such as the Papanicolaou Prize in 1975 and the first Founders Award of the Chemical Institute of Toxicology in 1978 and the Gairdner Foundation International Award .

Elizabeth Miller had two daughters with James A. Miller.

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Individual evidence

  1. ↑ Yoshida Tomizō was able to prove that such a dye can cause cancer in the mid-1930s in Japan
personal data
SURNAME Miller, Elizabeth C.
ALTERNATIVE NAMES Miller, Elizabeth Cavert
BRIEF DESCRIPTION American biochemist
DATE OF BIRTH May 2, 1920
PLACE OF BIRTH Minneapolis , Minnesota
DATE OF DEATH October 14, 1987