Enteroxyntin

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Enterooxyntin is a suspected peptide hormone that is produced in intestinal endocrine cells and is said to stimulate gastric juice secretion in the stomach.

Assumed function

The stimulation of gastric acid secretion can be divided into three phases, called cephalic phase ("head phase"), gastric phase (" stomach phase ") and intestinal phase ("bowel phase"). In the intestinal phase, pre-digested food pulp ( chyme ) passes from the stomach into the intestine and comes into contact with the mucous membrane of the duodenum and the subsequent section of the small intestine . This can lead to an additional increase in gastric acid secretion, which, however, only accounts for up to about 10% of the total production.

Stomach acid is produced by the parietal cells (parietal cells, also oxyntic cells ) in the fundus and body of the stomach , i.e. in the preceding part of the digestive tract . Their stimulation in this phase is mediated on the one hand by gastrin (released by G cells of the anterior duodenum) and on the other by protein breakdown products (free amino acids ) that reach the parietal cells via the circulating blood.

In addition, by stretching the wall of the small intestine, intestinal endocrine disrupting cells should also be stimulated to release a certain peptide hormone that stimulates gastric acid secretion, the so-called "entero-oxyntin". It has been suggested that enterooxyntin could increase the stimulatory effects of gastrin , histamine or even bethanechol (especially in animals), but a corresponding hormone has not yet been identified. The effect of the accepted hormone is interrupted by a cholinergic blockade. Contrary to other assumptions, enterooxyntin is not identical to gastrotropin . This 1989 publication is the last publication on Enterooxyntin in the PubMed database . To date, enteroxyntin has not been clearly identified.

Individual evidence

  1. ↑ WA Walker, WE Strodel, FE Eckhauser, A. Heldsinger, AI Vinik: = Enterooxyntin release from isolated perfused canine jejunum . In: J Surg Res . Vol. 34, No. 5 , May 1983, pp. 486-492 , PMID 6843113 (English).
  2. ^ Rodney A. Rhoades, David R. Bell: Medical Phisiology: Principles for Clinical Medicine . Lippincott Williams & Wilkins, 2012, ISBN 978-1-60913-427-3 ( full text in Google book search).
  3. ↑ a b Harvey J. Dworken: Gastroenterology: Pathophysiology and Clinical Applications . Butterworth-Heinemann, 2014, p. 680 ( full text in Google Book Search).
  4. ↑ I. Gantz, SF-defense, M. Lucey, JC Sacchettini, J. DelValle, LJ Banaszak, M. Naud, JI Gordon, T. Yamada: Gastrotropin: not an enterooxyntin but a member of a family of cytoplasmic hydrophobic ligand binding proteins . In: The Journal of biological chemistry. Volume 264, Number 34, December 1989, pp. 20248-20254, PMID 2584215 .
  5. ↑ Pubmed database query: Enterooxyntin .
  6. ^ Tadataka Yamada: Textbook of Gastroenterology. John Wiley & Sons, 2011, ISBN 978-1-4443-5941-1 , PT658.