Gastrotropin

Gastrotropin
other names	Fatty acid-binding protein 6, FABP6, Ileal lipid-binding protein, ILBP
	Existing structure data : PDB 1O1U , PDB 1O1V , PDB 2MM3
Properties of human protein
Mass / length primary structure	128 amino acids , 14,371 Da
Identifier
External IDs	GeneCards : FABP6 ; OMIM : 600422 ; UniProt : P51161 ;
	Orthologue (human)
Entrez	2172
Ensemble	ENSG00000170231
UniProt	P51161
Refseq (mRNA)	NM_001040442.1
Refseq (protein)	NP_001035532.1
PubMed search	2172

Gastrotropin is a transport protein from lipid metabolism .

properties

Gastrotropin binds to bile acids and mediates the transport from the apical cell membrane to the basement membrane in enterocytes of the intestine. Gastrotropin is produced in different isoforms . Isoform 1 is formed in parts of the intestine ( jejunum , ileum , caecum and in the ascending colon , but not in the subsequent part). Isoform 2 occurs in the bile and in the intestine, as well as in colorectal adenocarcinomas . The tendency to bind is in the order deoxycholic acid > cholic acid > chenodeoxycholic acid and in the order according to their respective modifications taurine -conjugated> glycine -conjugated> unconjugated.

In colon cancer, isoform 2 is responsible for apoptosis resistance to bile acids. The suspected hormone enterooxyntin was previously mistaken for gastrotropin. Inhibition of gastrotropin is being investigated for the treatment of diabetes mellitus .

Web links

MeSH gastrotropin

Individual evidence

↑ BL Zwicker, LB Agellon: Transport and biological activities of bile acids. In: The international journal of biochemistry & cell biology. Volume 45, Number 7, July 2013, pp. 1389-1398, doi : 10.1016 / j.biocel.2013.04.012 , PMID 23603607 .
↑ AG Hendrick, I. Müller, H. Willems, PM Leonard, S. Irving, R. Davenport, T. Ito, J. Reeves, S. Wright, V. Allen, S. Wilkinson, H. Heffron, R. Bazin , J. Turney, PJ Mitchell: Identification and Investigation of Novel Binding Fragments in the Fatty Acid Binding Protein 6 (FABP6). In: Journal of medicinal chemistry. Volume 59, Number 17, September 2016, pp. 8094-8102, doi : 10.1021 / acs.jmedchem.6b00869 , PMID 27500412 .

[1] BL Zwicker, LB Agellon: Transport and biological activities of bile acids. In: The international journal of biochemistry & cell biology. Volume 45, Number 7, July 2013, pp. 1389-1398, doi : 10.1016 / j.biocel.2013.04.012 , PMID 23603607 .

[2] AG Hendrick, I. Müller, H. Willems, PM Leonard, S. Irving, R. Davenport, T. Ito, J. Reeves, S. Wright, V. Allen, S. Wilkinson, H. Heffron, R. Bazin , J. Turney, PJ Mitchell: Identification and Investigation of Novel Binding Fragments in the Fatty Acid Binding Protein 6 (FABP6). In: Journal of medicinal chemistry. Volume 59, Number 17, September 2016, pp. 8094-8102, doi : 10.1021 / acs.jmedchem.6b00869 , PMID 27500412 .