Erich Nigg

Erich Nigg, 2011

Erich Alois Nigg (born November 28, 1952 in Uster ) is a Swiss cell biologist and former director of the Biozentrum of the University of Basel .

Life

Erich Nigg received his doctorate in 1980 from the ETH Zurich ( biochemistry ). He then did research at the University of California in San Diego, the ETH Zurich and the Swiss Institute for Experimental Cancer Research (ISREC). From 1995 he was Professor of Molecular Biology at the University of Geneva before becoming Director at the Max Planck Institute for Biochemistry in Martinsried (Germany) in 1999 . From 2009 to 2018 Erich Nigg was Professor of Cell Biology and Director of the Biozentrum at the University of Basel.

Act

After early work on biological membranes , the structure of the cell nucleus and mechanisms of signal transmission in the cell nucleus, Erich Nigg concentrated on researching the cell cycle . His research results are fundamental to understanding the distribution of human chromosomes during cell division , the control of mitosis , and the elucidation of the structure and function of centrosomes . This work is medically relevant because disturbances in mitotic processes contribute to the genetic instability of cancer cells and centrosome anomalies cause diseases (brain diseases and ciliopathies). In addition, cell cycle control enzymes ( protein kinases ) are attractive target molecules for new therapeutic agents.

Awards and memberships

• 1991: elected member of the European Molecular Biology Organization (EMBO)
• 1992: Friedrich Miescher Prize
• 1993: Robert Wenner Prize for Cancer Research
• 1998: elected member of the Academia Europaea
• 2004: Meyenburg Prize from the Wilhelm and Maria Meyenburg Foundation
• 2005: elected member of the German Academy of Sciences Leopoldina in Germany
• 2009: elected member of the European Academy of Cancer Sciences

List of publications

• with RJ Cherry: Dimeric association of band 3 in the erythrocyte membrane demonstrated by protein diffusion measurements. In: Nature. v277 (5696), 1979, pp. 493-494.
• with G. Schäfer, H. Hilz and HM Eppenberger: Cyclic-AMP-dependent protein kinase type II is associated with the Golgi complex and with centrosomes. In: Cell. 41 (3), 1985, pp. 1039-1051.
• with RA Borer, CF Lehner and HM Eppenberger: Major nucleolar proteins shuttle between nucleus and cytoplasm. In: Cell. 56 (3), 1989, pp. 379-390.
• with M. Peter, J. Nakagawa, M. Dorée and JC Labbé: Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase. In: Cell. 60 (5), 1990, pp. 791-801.
• with M. Peter, J. Nakagawa, M. Dorée and JC Labbé: In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase. In: Cell. 61 (4), 1990, pp. 591-602.
• with MS Schmidt-Zachmann, C. Dargemont and LC Kühn: Nuclear export of proteins: the role of nuclear retention. In: Cell. 74 (3), 1993, pp. 493-504.
• with A. Blangy, HA Lane, P. d'Hérin, M. Harper and M. Kress: Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. In: Cell. 83 (7), 1995, pp. 1159-1169.
• with P. Meraldi, J. Lukas, AM Fry and J. Bartek: Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. In: Nat Cell Biol. 1 (2), 1999, pp. 88-93.
• with S. Martin-Lluesma and VM Stucke: Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1 / Mad2. In: Science. 297 (5590), 2002, pp. 2267-2270.
• with JS Andersen, CJ Wilkinson, T. Mayor, P. Mortensen and M. Mann: Proteomic characterization of the human centrosome by protein correlation profiling. In: Nature. 426 (6966), 2003, pp. 570-574.
• with M. Casenghi, P. Meraldi, U. Weinhart, PI Duncan and R. Körner: Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. In: Dev Cell. 5 (1), 2003, pp. 113-125.
• with R. Habedanck, YD Stierhof and CJ Wilkinson: The Polo kinase Plk4 functions in centriole duplication. In: Nat Cell Biol. 7 (11), 2005, pp. 1140-1146.
• with C. Baumann, R. Körner and K. Hofmann: PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint. In: Cell. 128 (1), 2007, pp. 101-114.
• with J. Kleylein-Sohn, J. Westendorf, M. Le Clech, R. Habedanck and YD Stierhof: Plk4-induced centriole biogenesis in human cells. In: Dev Cell. 13 (2), 2007, pp. 190-202.
• with A. Santamaria, B. Wang, S. Elowe, R. Malik, F. Zhang, M. Bauer, A. Schmidt, HH Silljé and R. Körner: The Plk1-dependent phosphoproteome of the early mitotic spindle. In: Mol Cell Proteomics. 10 (1), 2011, p. M110.004457.

Web links

• Biozentrum of the University of Basel
• University of Basel
• Wilhelm and Maria Meyenburg Foundation
• Member entry by Erich A. Nigg at the German Academy of Natural Scientists Leopoldina , accessed on April 12, 2015.
• Interview Radio SRF2 "From« Paradise »to the Basel Biozentrum". Retrieved June 1, 2013 . 

Individual evidence

1. ^ Farewell symposium Prof. Erich Nigg, Director of the Biozentrum, on February 1, 2018
2. ^ Research group
3. ↑ Member entry by Prof. Dr. Erich A. Nigg (with picture and CV) at the German Academy of Natural Scientists Leopoldina , accessed on July 15, 2016.
4. ↑ List of publications ( Memento of the original from May 19, 2013 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice.