Cell division protein FtsZ
| Cell division protein FtsZ1 ( Methanococcus jannaschii ) | ||
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| Ribbon model of the structure of FtsZ1 from Methanococcus jannaschii , according to PDB 1FSZ | ||
| Mass / length primary structure | 364 amino acids | |
| Secondary to quaternary structure | aggregated into a ring | |
| Identifier | ||
| Gene name (s) | ftsZ | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.6.5.- , GTPase | |
| Response type | Polymerization | |
| Substrate | 2 FtsZ + GTP | |
| Products | FtsZ 2 + GDP + P i | |
| Occurrence | ||
| Parent taxon | Bacteria, some archaea, chloroplasts | |
FtsZ is in bacteria , some archaea and in the chloroplast occurring plant protein , which as a structural protein in the cell division plays a role. It is considered a prokaryotic homolog of eukaryotic tubulin . FtsZ is encoded by the gene of the same name ftsZ .
The name FtsZ is derived from the acronym for " F ilamenting t emperature- s ensitive mutant Z " from; these mutants of Escherichia coli grow filamentously in length as a result of a loss of function of the ftsZ gene and the associated inability to divide cells.
Although the gene was published by Y. Hirota et al . was discovered in the course of their studies on E. coli mutants with impaired division , the FtsZ protein was only later described as the first representative of the prokaryotic cytoskeleton . In 1991, Erfei Bi and Joseph Lutkenhaus postulated the participation of FtsZ in the formation of the so-called Z-ring. As FtsZ forms a ring at the future position of the septum, to which further, division-relevant proteins are later recruited, it initiates the bacterial division process. FtsZ binds FtsA .
In 1998 Ralf Reski et al . the first eukaryotic FtsZ proteins discovered in Physcomitrella patens . These proteins play a role in plastid division ; they are encoded in the cell nucleus and have specific signal sequences for import into chloroplasts .
Individual evidence
- ↑ IPR020805 Cell division protein FtsZ, conserved site. In: InterPro 31.0. EBI, accessed March 19, 2011 .
- ↑ Ishikawa, Hajime; Kuroiwa, Tsuneyoshi; Nagata, Kazuhiro .: 『細胞 生物学 事 典』 . 朝 倉 書店, 2005, ISBN 978-4-254-17118-1 , pp. 159-160.
- ↑ Bi EF, Lutkenhaus J : FtsZ ring structure associated with division in Escherichia coli . In: Nature . 354, No. 3-5, 1991, pp. 161-164. doi : 10.1038 / 354161a0 . PMID 1944597 .
- ^ Strepp R., Scholz S., Kruse S., Speth V., Reski R .: Plant nuclear gene knockout reveals a role in plastid division for the homolog of the bacterial cell division protein FtsZ, an ancestral tubulin . In: Proceedings of the National Academy of Science USA . 95, 1998, pp. 4368-4373. PMID 9539743 .