Ralf Reski

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Ralf Reski, 2018

Ralf Reski (born November 18, 1958 in Gelsenkirchen ) is a German professor of plant biotechnology and former dean of the Faculty of Biology at the Albert Ludwig University of Freiburg .

Life

Ralf Reski studied biology , chemistry and education at the Universities of Giessen and Hamburg . He completed his doctorate in genetics in 1990 at the University of Hamburg, his habilitation in general botany followed in 1994. From 1996 to 1999 he was a Heisenberg fellow of the German Research Foundation (DFG) . He is married and has two sons

Following offers from domestic and foreign universities, he was appointed professor and full professor at the University of Freiburg in 1999 and was given the newly founded chair for plant biotechnology. Since 2004 he has also been teaching at the École supérieure de biotechnologie Strasbourg (ESBS). From 2001 to 2011 he was director of the plant biotechnology section at the Center for Applied Biosciences (ZAB). In 2004 he became a member of the International Moosgenom Consortium. Reski is also a founding member of four institutions funded by the Excellence Initiative: Spemann Graduate School for Biology and Medicine (SGBM), the Center for Integrative Biological Signaling Studies (CIBSS) , the Cluster Living, Adaptive and Energy-Autonomous Materials Systems (livMATs) and the Excellence Cluster Center for Biological Signaling Studies (bioss). Reski is also a founding member of the Freiburg Initiative for Systems Biology (FRISYS) funded by the BMBF as part of FORSYS . In 2003 Ralf Reski became a member of the Supervisory Board of BIOPRO Baden-Württemberg GmbH and was appointed by Finance Minister Willi Stächele for a further term of office in 2009, which ended in 2012. From 2007 to 2010 Reski was a member of the Baden-Württemberg Innovation Council of the then Prime Minister and current EU Commissioner Günther Oettinger .

From March 2008 to March 2012 Reski was chairman of the DNK, the German National Biology Committee . In this position he was a member of the advisory board of the Association of Biology, Biosciences and Biomedicine in Germany (VBIO) from September 2008 to March 2012 . At the 30th General Assembly of the International Union of Biological Sciences (IUBS) Reski was elected to the extended board of this non-profit organization , of which he was a member until 2012. In 2011 Ralf Reski was appointed as a fellow at the Freiburg Institute for Advanced Studies (FRIAS) and was elected for life as a member of the Heidelberg Academy of Sciences .

Reski is one of the co-founders of the Trinational Institute for Plant Research. Since 2010 he has been the elected senator and speaker of the professors in the Academic Senate of the University of Freiburg. In 2012 Ralf Reski organized the Plant Biology Congress, which was attended by over 1000 scientists from 60 countries. Reski has been a fellow at the University of Strasbourg at the Institute for Advanced Study (Institut d'Etudes Avancées, USIAS) since 2013 . Since 2015 he has been coordinating the international Erasmus program "Trans-regional environmental awareness for sustainable usage of water resources" - or TREASURE-WATER for short of the European Union , which is used for university education and knowledge transfer in order to sustainably increase the common water resources of Russia and Kazakhstan use.

research

Moss bioreactor with Physcomitrella patens

In his scientific work, Ralf Reski mainly deals with moss plants and examines genetics , proteins , metabolism and special features in the cell development of mosses and uses the very efficient homologous recombination to produce knockout mosses . With over 250 scientific publications, he has played a key role in ensuring that mosses are recognized worldwide as model organisms in biological research. The complete genetic material of the small bladder cap moss ( Physcomitrella patens ) was deciphered in December 2007. This work was largely funded by the US Department of Energy and the DFG . In 2010 he founded the International Moss Stock Center (IMSC), a biobank that stores and distributes moss plants from all over the world. This resource center issues “accession numbers” for the stored mosses, which can be used for publication purposes.

As biotechnologists, Reski and colleagues identify previously unknown genes and their role in agriculture and forestry . But also the production of complex biopharmaceuticals in the moss bioreactor , the so-called molecular pharming , and their use for the pharmaceutical industry are among his main research areas. The working group uses methods from bioinformatics , systems biology and synthetic biology , for example in the bioss excellence cluster and in the FORSYS program launched by the BMBF .

Ralf Reski coined the term “ plastoskeleton ” in 2000 in analogy to the term “ cytoskeleton ” and thus presented a new concept for cell biology , how chloroplasts , the green cell organelles of plants, change their shape and divide.

In 1999, BASF invested more than DM 30 million in an initially four-year cooperation with Reski to jointly discover new genes that can make crops more resistant to drought , cold and pest infestation . But plants with improved ingredients such as vitamins and polyunsaturated fatty acids were also in the joint research interest.

Also in 1999 Ralf Reski co-founded the biotechnology company greenovation Biotech GmbH in Freiburg im Breisgau . greenovation has developed a moss bioreactor for the biotechnological production of active pharmaceutical ingredients, which is a safe and cost-effective alternative to other production systems. In 2017, the first clinical phase 1 study for the analysis of the enzyme α-galactosidase A produced in mosses for the treatment of the metabolic disorder Fabry disease was completed.

In 2010 Reski and colleagues discovered a new mechanism of gene regulation in eukaryotes, epigenetic gene silencing by microRNAs

Reski is involved in the Mossclone project, a European funding program that is funded in the FP7 research framework program. In it, scientists are researching a new biotechnological process to monitor air quality with mosses . This should serve to improve the previous pollutant monitoring in the air.

2016 identified Reski and his team a homeobox gene as a key regulator for the development of moss - embryo , a fundamental mechanism for the development of stomata and in 2017 they described that the cuticle is a precursor in the evolution of lignin was.

In 2018 Reski and other researchers investigated six RecQ helicases in the little bladder cap moss ( Physcomitrella patens ) and in the cress wall ( Arabidopsis thaliana ). They found that the RecQ4 protein in moss is orthologous to the Bloom syndrome protein . It acts as a repressor of homologous recombination , protects the genome from mutations and is crucial for the development of the embryo and the subsequent development of the plant . In contrast, the RecQ6 protein in moss improves gene targeting .

Membership in scientific advisory boards

Membership in the editorial board of professional journals

  • 2002–2012: Plant Cell Reports
  • 2004–2005: Plant Biology (guest editor)
  • 2008-2013: Journal of Biomedicine and Biotechnology
  • 2010–2012: Biology International

Web links

Individual evidence

  1. ↑ CV
  2. ↑ CV. Retrieved June 23, 2019 .
  3. ↑ moss genome consortium - Members mossgenome.org ( Memento of 19 December 2007 at the Internet Archive )
  4. ↑ Profile - SGBM sgbm.uni-freiburg.de
  5. ↑ Website of the Center for Integrative Biological Signaling Studies (CIBSS)
  6. ^ Website of the Cluster Living, Adaptive and Energy-autonomous Materials Systems (livMatS)
  7. ↑ BIOSS Team University of Freiburg www.bioss.uni-freiburg.de accessed on 2019-06-26
  8. ↑ FRISYS - members FRISYS participants ( Memento from March 6, 2012 in the Internet Archive )
  9. ↑ Supervisory Board of BioPro bio-pro.de
  10. ↑ Interim balance sheet of the Innovation Council (2009) Baden-Württemberg.de accessed on 2019-06-26
  11. ^ Final documentation of the Innovation Council (2010) Baden-Württemberg.de accessed on 2019-06-26
  12. ↑ DNK Board iubs-member-germany.de
  13. ↑ Advisory Board of VBIO vbio.de ( Memento from July 21, 2009 in the Internet Archive )
  14. ↑ Former IUBS board member
  15. ↑ FRIAS fellow Ralf Reski FRIAS fellows, University of Freiburg ( Memento from April 1, 2012 in the Internet Archive )
  16. ^ The members of the HAW since it was founded in 1909 haw.uni-heidelberg.de
  17. ↑ Key technology: Cooperation in the triangle pr.uni-freiburg.de
  18. ↑ senat.uni-freiburg.de
  19. ↑ alphagalileo.org
  20. ↑ Institute for Advanced Study University of Strasbourg (Institut d'Etudes Avancées, USIAS) www.usias.fr/en/ accessed on 2019-06-26
  21. ^ University of Freiburg
  22. ↑ official TREASURE WATER project website
  23. ^ R. Reski: Physcomitrella and Arabidopsis: the David and Goliath of reverse genetics. In: Trends in Plant Science. 3, 1998, pp. 209-210. doi: 10.1016 / S1360-1385 (98) 01257-6
  24. ^ Rensing et al .: The Physcomitrella Genome Reveals Evolutionary Insights into the Conquest of Land by Plants. In: Science . 319, 2008, pp. 64-69. doi: 10.1126 / science.1150646
  25. ^ Doe Joint Genome Institute: Why sequence Physcomitrella patens? jgi.doe.gov
  26. ↑ Green Biobank in Freiburg puts mosses on ice (biotechnologie.de) biotechnologie.de ( Memento from March 5, 2011 in the Internet Archive )
  27. ^ R. Reski, W. Frank: Moss (Physcomitrella patens) functional genomics - Gene discovery and tool development with implications for crop plants and human health. In: Briefings in Functional Genomics & Proteomics. 4, 2005, pp. 48-57. doi: 10.1093 / bfgp / 4.1.48
  28. ↑ J. Kiessling et al. Visualization of a cytoskeleton-like FtsZ network in chloroplasts. In: Journal of Cell Biology . 151, 2000, pp. 945-950. doi: 10.1083 / jcb.151.4.945
  29. ^ GI McFadden: Comment: Skeleton in the closet: How do chloroplasts stay in shape? In: Journal of Cell Biology. 151, 2000, pp. F19-F21. jcb.rupress.org
  30. ^ R. Reski: Rings and networks: the amazing complexity of FtsZ in chloroplasts. In: Trends in Plant Science. 7, 2002, pp. 103-105. doi: 10.1016 / S1360-1385 (02) 02232-X
  31. ↑ Quirin Schiermeier: German / Swedish venture creates plant biotechnology giant . In Nature Vol. 397, p. 283 (1999). doi: 10.1038 / 16754 .
  32. ^ EL Decker, R. Reski: Current achievements in the production of complex biopharmaceuticals with moss bioreactor. In: Bioprocess and Biosystems Engineering. 31, 2008, pp. 3-9. doi: 10.1007 / s00449-007-0151-y
  33. ↑ Small moss with a great future biotechnologie.de ( Memento from November 29, 2009 in the Internet Archive )
  34. ↑ Greenovation achieves the breakthrough portal goingpublic
  35. ↑ B. Khraiwesh et al .: Transcriptional Control of Gene Expression by MicroRNAs. In: Cell. 140, 2010, pp. 111-122. doi: 10.1016 / j.cell.2009.12.023
  36. ↑ RNA snippets switch genes directly off biotechnologie.de ( Memento from March 5, 2011 in the Internet Archive )
  37. ↑ Video of the Euronews portal “Mosses should control air pollution” June 3, 2013; accessed October 30, 2013.
  38. ^ NA Horst et al .: A single homeobox gene triggers phase transition, embryogenesis and asexual reproduction. In: Nature Plants. 2, 2016, p. 15209. doi: 10.1038 / nplants.2015.209
  39. ^ CC Chater et al .: Origin and function of stomata in the moss Physcomitrella patens. In: Nature Plants. 2, 2016, p. 16179. doi: 10.1038 / NPLANTS.2016.179
  40. ^ H. Renault et al .: A phenol-enriched cuticle is ancestral to lignin evolution in land plants. In: Nature Communications. 8, 2017, p. 14713. doi: 10.1038 / ncomms14713 .
  41. ^ A b Wiedemann, G., N. van Gessel, F. Köchl, L. Hunn, K. Schulze, L. Maloukh, F. Nogué, EL Decker, F. Hartung, R. Reski (2018): RecQ helicases function in development, DNA repair and gene targeting in Physcomitrella patens . Plant Cell 30 , 717-736. doi : 10.1105 / tpc.17.00632
  42. ↑ RecQ Proteins: Masters of Genome Surveillance. The Plant Cell: In a Nutshell. Plantae
  43. ↑ http://www.bio-pro.de/magazin/index.html?lang=en&artikelid=/artikel/08000/index.html
  44. ^ Article in the Badische Zeitung
  45. ↑ Interim balance sheet of the Innovation Council (2009) Baden-Württemberg.de accessed on 2019-06-26
  46. ^ Final documentation of the Innovation Council (2010) Baden-Württemberg.de accessed on 2019-06-26
  47. ^ Website of the DNK
  48. ↑ https://www.vbio.de/beirat/
  49. ^ Former board members, IUBS website
  50. ↑ Appointment of the scientific advisory board of CeBiTec
  51. ↑ springer.com
  52. ↑ springer.com
  53. ↑ Interview in ZEIT zeit.de
  54. ↑ iubs.org
personal data
SURNAME Reski, Ralf
BRIEF DESCRIPTION German biologist and university professor
DATE OF BIRTH November 18, 1958
PLACE OF BIRTH Gelsenkirchen