Tyrosine kinase Fyn

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Tyrosine kinase Fyn
Properties of human protein
Mass / length primary structure 537 amino acids
Cofactor Mn 2+
Isoforms B, T, P06421-3
Identifier
Gene name FYN
External IDs
Enzyme classification
EC, category 2.7.10.2 ,  tyrosine kinase
Response type Phosphorylation of tyrosine residues in proteins
Substrate Xaa-Tyr-Yaa + ATP
Products Xaa-TyrP-Yaa + ADP
Occurrence
Parent taxon Vertebrates
Orthologue
human House mouse
Entrez 2534 14360
Ensemble ENSG00000010810 ENSMUSG00000019843
UniProt P06241 P39688
Refseq (mRNA) NM_002037 NM_001122892
Refseq (protein) NP_002028 NP_001116364
Gene locus Chr 6: 111.66 - 111.87 Mb Chr 10: 39.37 - 39.57 Mb
PubMed search 2534 14360

The tyrosine kinase Fyn is an enzyme in vertebrates that catalyzes the phosphorylation of several proteins on the amino acid tyrosine ( tyrosine kinase ). This reaction is part of around a dozen signaling pathways that are essential for the embryonic development of the brain and its subsequent function. In humans, Fyn controls the growth of axons and the calcium content of cells. Of the three known isoforms 'B' is particularly in the brain and 'T' in T cells expressed .

Interactions

Some interactions with other proteins have been demonstrated for FYN .

literature

Sources, citations, journal articles

  1. ↑ Orthologist at OMA
  2. ↑ UniProt P06421
  3. ^ T Shima, Okumura N, Takao T, Satomi Y, Yagi T, Okada M, Nagai K: Interaction of the SH2 domain of Fyn with a cytoskeletal protein, beta-adducin . In: J. Biol. Chem. . 276, No. 45, United States, November 2001, ISSN  0021-9258 , pp. 42233-40. doi : 10.1074 / jbc.M102699200 . PMID 11526103 .
  4. ^ A b Corinna Klein, Kramer Eva-Maria, Cardine Anne-Marie, Schraven Burkhardt, Brandt Roland, Trotter Jacqueline: Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau . In: J. Neurosci. . 22, No. 3, United States, February 2002, pp. 698-707. PMID 11826099 .
  5. ↑ JC Donaldson, Dempsey PJ, Reddy S, Bouton AH, Coffey RJ, Hanks SK: Crk-associated substrate p130 (Cas) interacts with nephrocystine and both proteins localize to cell-cell contacts of polarized epithelial cells . In: Exp. Cell Res . 256, No. 1, United States, April 2000, ISSN  0014-4827 , pp. 168-78. doi : 10.1006 / excr.2000.4822 . PMID 10739664 .
  6. ↑ SN Manié, Astier A, Haghayeghi N, Canty T, Druker BJ, Hirai H, Freedman AS: Regulation of integrin-mediated p130 (Cas) tyrosine phosphorylation in human B cells. A role for p59 (Fyn) and SHP2 . In: J. Biol. Chem. . 272, No. 25, United States, June 1997, ISSN  0021-9258 , pp. 15636-41. doi : 10.1074 / jbc.272.25.15636 . PMID 9188452 .
  7. ↑ Taher EI Taher, Tjin Esther PM, Beuling Esther A, Borst Jannie, Spaargaren Marcel, Pals Steven T: c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination . In: J. Immunol. . 169, No. 7, United States, October 2002, ISSN  0022-1767 , pp. 3793-800. PMID 12244174 .
  8. ↑ a b M Deckert, Elly C, Altman A, Liu YC: Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases . In: J. Biol. Chem. . 273, No. 15, United States, April 1998, ISSN  0021-9258 , pp. 8867-74. doi : 10.1074 / jbc.273.15.8867 . PMID 9535867 .
  9. ↑ M Kim, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T: Molecular cloning and characterization of a novel cbl-family gene, cbl-c . In: Genes . 239, No. 1, NETHERLANDS, October 1999, ISSN  0378-1119 , pp. 145-54. doi : 10.1016 / S0378-1119 (99) 00356-X . PMID 10571044 .
  10. ↑ MM Huang, Bolen JB, Barnwell JW, Shattil SJ, Brugge JS: Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets . In: Proc. Natl. Acad. Sci. USA . 88, No. 17, United States, September 1991, ISSN  0027-8424 , pp. 7844-8. doi : 10.1073 / pnas.88.17.7844 . PMID 1715582 . PMC 52400 (free full text).
  11. ↑ HA Bull, Brickell PM, Dowd PM: Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells . In: FEBS Lett . . 351, No. 1, NETHERLANDS, August 1994, ISSN  0014-5793 , pp. 41-4. doi : 10.1016 / 0014-5793 (94) 00814-0 . PMID 7521304 .
  12. ↑ S Ilangumaran, Briol A, Hoessli DC: CD44 Selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes . In: Blood . 91, No. 10, United States, May 1998, ISSN  0006-4971 , pp. 3901-8. PMID 9573028 .
  13. ↑ a b Jose Piedra, Miravet Susana, Castaño Julio, Pálmer Héctor G, Heisterkamp Nora, García de Herreros Antonio, Duñach Mireia: p120 Catenin -associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha -catenin Interaction . In: Mol. Cell. Biol . 23, No. 7, United States, April 2003, ISSN  0270-7306 , pp. 2287-97. doi : 10.1128 / MCB.23.7.2287-2297.2003 . PMID 12640114 . PMC 150740 (free full text).
  14. ↑ T Kihara, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A: alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity . In: J. Biol. Chem. . 276, No. 17, United States, April 2001, ISSN  0021-9258 , pp. 13541-6. doi : 10.1074 / jbc.M008035200 . PMID 11278378 .
  15. ↑ SA Courtneidge, Dhand R, D Pilat, Twamley GM, Waterfield MD, Roussel MF: Activation of Src family kinases by colony stimulating factor-1, and Their association with its receptor . In: EMBO J. . 12, No. 3, ENGLAND, March 1993, ISSN  0261-4189 , pp. 943-50. PMID 7681396 . PMC 413295 (free full text).
  16. ↑ V Cleghon, Morrison DK: Raf-1 inter-acts with Fyn and Src in a non-phosphotyrosine-dependent manner . In: J. Biol. Chem. . 269, No. 26, United States, July 1994, ISSN  0021-9258 , pp. 17749-55. PMID 7517401 .
  17. ↑ Maria Cruz Martinez, Ochiishi Tomoyo, Majewski Michael, Kosik Kenneth S: Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho . In: J. Cell Biol. . 162, No. 1, United States, July 2003, ISSN  0021-9525 , pp. 99-111. doi : 10.1083 / jcb.200211025 . PMID 12835311 . PMC 2172717 (free full text).
  18. ↑ a b T Tezuka, Umemori H, Akiyama T, Nakanishi S, Yamamoto T: PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A . In: Proc. Natl. Acad. Sci. USA . 96, No. 2, United States, January 1999, ISSN  0027-8424 , pp. 435-40. doi : 10.1073 / pnas.96.2.435 . PMID 9892651 . PMC 15154 (free full text).
  19. ↑ a b Xiao-Yu Hou, Zhang Guang-Yi, Yan Jing-Zhi, Chen Min, Liu Yong: Activation of NMDA receptors and L-type voltage-gated calcium channels mediates enhanced formation of Fyn-PSD95-NR2A complex after transient brain ischemia . In: Brain Res. . 955, No. 1-2, Netherlands, November 2002, ISSN  0006-8993 , pp. 123-32. doi : 10.1016 / S0006-8993 (02) 03376-0 . PMID 12419528 .
  20. ↑ F Sotgia, Lee H, Bedford MT, Petrucci T, Sudol M, Lisanti MP: Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins . In: Biochemistry . 40, No. 48, United States, December 2001, ISSN  0006-2960 , pp. 14585-92. doi : 10.1021 / bi011247r . PMID 11724572 .
  21. ↑ S Choi, Park S: Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity . In: Oncogene . 18, No. 39, ENGLAND, September 1999, ISSN  0950-9232 , pp. 5413-22. doi : 10.1038 / sj.onc.1202917 . PMID 10498895 .
  22. ^ J Wenzel, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O: Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor . In: FEBS Lett. . 509, No. 2, Netherlands, December 2001, ISSN  0014-5793 , pp. 255-62. doi : 10.1016 / S0014-5793 (01) 03174-X . PMID 11741599 .
  23. ↑ M Hane, Lowin B, Peitsch M, Becker K, Tschopp J: Interaction of peptides derived from the Fas ligand with the Fyn-SH3 domain . In: FEBS Lett. . 373, No. 3, NETHERLANDS, October 1995, ISSN  0014-5793 , pp. 265-8. doi : 10.1016 / 0014-5793 (95) 01051-F . PMID 7589480 .
  24. ↑ AJ da Silva, Janssen O, Rudd CE: T cell receptor zeta / CD3-p59fyn (T) -associated p120 / 130 binds to the SH2 domain of p59fyn (T) . In: J. Med.. . 178, No. 6, United States, December 1993, ISSN  0022-1007 , pp. 2107-13. doi : 10.1084 / jem.178.6.2107 . PMID 7504057 . PMC 2191307 (free full text).
  25. ↑ a b A Marie-Cardine, Hendricks-Taylor LR, Boerth NJ, Zhao H, Schraven B, Koretzky GA: Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130 . In: J. Biol. Chem. . 273, No. 40, United States, October 1998, ISSN  0021-9258 , pp. 25789-95. doi : 10.1074 / jbc.273.40.25789 . PMID 9748251 .
  26. ↑ Rami Yaka, He Dao-Yao, Phamluong Khanhky, Ron Dorit: Pituitary adenylate cyclase-activating polypeptide (PACAP (1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1 . In: J. Biol. Chem. . 278, No. 11, United States, March 2003, ISSN  0021-9258 , pp. 9630-8. doi : 10.1074 / jbc.M209141200 . PMID 12524444 .
  27. ↑ Rami Yaka, Thornton Claire, Vagts Alicia J, Phamluong Khanhky, Bonci Antonello, Ron Dorit: NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1 . In: Proc. Natl. Acad. Sci. USA . 99, No. 8, United States, April 2002, ISSN  0027-8424 , pp. 5710-5. doi : 10.1073 / pnas.062046299 . PMID 11943848 . PMC 122836 (free full text).
  28. ↑ Juan Ma, Zhang Guang-Yi: Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia . In: Neurosci. Lett. . 348, No. 3, Ireland, September 2003, ISSN  0304-3940 , pp. 185-9. doi : 10.1016 / S0304-3940 (03) 00784-5 . PMID 12932824 .
  29. ↑ N Takagi, Cheung HH, Bissoon N, Teves L, Wallace MC, Gurd JW: The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains . In: J. Cereb. Blood flow metab. . 19, No. 8, United States, August 1999, ISSN  0271-678X , pp. 880-8. doi : 10.1097 / 00004647-199908000-00007 . PMID 10458595 .
  30. ↑ SC Bunnell, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ: Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade . In: J. Biol. Chem. . 275, No. 3, United States, January 2000, ISSN  0021-9258 , pp. 2219-30. doi : 10.1074 / jbc.275.3.2219 . PMID 10636929 .
  31. ^ SC Bunnell, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ: Identification of Itk / Tsk Src homology 3 domain ligands . In: J. Biol. Chem. . 271, No. 41, United States, October 1996, ISSN  0021-9258 , pp. 25646-56. doi : 10.1074 / jbc.271.41.25646 . PMID 8810341 .
  32. ↑ PP Sayeski, Ali MS, Safavi A, Lyles M, Kim SO, Frank SJ, Bernstein KE: A catalytically active Jak2 is required for the angiotensin II-dependent activation of Fyn . In: J. Biol. Chem. . 274, No. 46, United States, November 1999, ISSN  0021-9258 , pp. 33131-42. doi : 10.1074 / jbc.274.46.33131 . PMID 10551884 .
  33. ↑ Chitose Oneyama, Nakano Hirofumi, Sharma Sreenath V: UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug . In: Oncogene . 21, No. 13, England, March 2002, ISSN  0950-9232 , pp. 2037-50. doi : 10.1038 / sj.onc.1205271 . PMID 11960376 .
  34. ↑ N Fusaki, Iwamatsu A, Iwashima M, Fujisawa Ji: Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling . In: J. Biol. Chem . 272, No. 10, United States, March 1997, ISSN  0021-9258 , pp. 6214-9. doi : 10.1074 / jbc.272.10.6214 . PMID 9045636 .
  35. ↑ Juhani Lahdenperä, Kilpeläinen Pekka, Liu Xiao Li, Pikkarainen Timo, Reponen Paula, Ruotsalainen Vesa, Tryggvason Karl: Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases . In: Kidney Int . 64, No. 2, United States, August 2003, ISSN  0085-2538 , pp. 404-13. doi : 10.1046 / j.1523-1755.2003.00097.x . PMID 12846735 .
  36. ↑ Rakesh Verma, Wharram Bryan, Kovari Iulia, Kunkel Robin, Nihalani Deepak, Wary Kishore K, Wiggins Roger C, Killen Paul, Holzman Lawrence B: Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin . In: J. Biol. Chem . 278, No. 23, United States, June 2003, ISSN  0021-9258 , pp. 20716-23. doi : 10.1074 / jbc.M301689200 . PMID 12668668 .
  37. ↑ T Brdicka, Pavlistová D, Leo A, Bruyns E, Korínek V, Angelisová P, Scherer J, Shevchenko A, Hilgert I, Cerný J, Drbal K, Kuramitsu Y, Kornacker B, Horejsí V, Schraven B: Phosphoprotein associated with glycosphingolipid -enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adapter protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation . In: J. Med.. . 191, No. 9, United States, May 2000, ISSN  0022-1007 , pp. 1591-604. doi : 10.1084 / jem.191.9.1591 . PMID 10790433 . PMC 2213442 (free full text).
  38. ↑ I Gout, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD: Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system . In: Biochem. J. . 288 (Pt 2), ENGLAND, December 1992, ISSN  0264-6021 , pp. 395-405. PMID 1334406 . PMC 1132024 (free full text).
  39. ^ D Ron, Napolitano EW, Voronova A, Vasquez NJ, Roberts DN, Calio BL, Caothien RH, Pettiford SM, Wellik S, Mandac JB, Kauvar LM: Direct interaction in T-cells between thetaPKC and the tyrosine kinase p59fyn . In: J. Biol. Chem. . 274, No. 27, United States, July 1999, ISSN  0021-9258 , pp. 19003-10. doi : 10.1074 / jbc.274.27.19003 . PMID 10383400 .
  40. ↑ Magdalena M. Gorska, Susan J. Stafford, Osman Cen, Sanjiv Sur, Rafeul Alam: Unc119, a Novel Activator of Lck / Fyn, Is Essential for T Cell Activation . In: The Journal of Experimental Medicine . tape 199 , no. 3 , 2004, ISSN  0022-1007 , p. 369–379 , doi : 10.1084 / jem.20030589 , PMID 14757743 , PMC 2211793 (free full text).
  41. ↑ Samantha Messina, Onofri Franco, Bongiorno-Borbone Lucilla, Giovedì Silvia, Valtorta Flavia, Girault Jean-Antoine, Benfenati Fabio: Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin . In: J. Neurochem. . 84, No. 2, England, January 2003, ISSN  0022-3042 , pp. 253-65. doi : 10.1046 / j.1471-4159.2003.01519.x . PMID 12558988 .
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  46. ↑ Sachiko Taniguchi, Liu Hui, Nakazawa Takanobu, Yokoyama Kazumasa, Tezuka Tohru, Yamamoto Tadashi: p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn . In: Biochem. Biophys. Res. Commun. . 306, No. 1, United States, June 2003, ISSN  0006-291X , pp. 151-5. doi : 10.1016 / S0006-291X (03) 00923-9 . PMID 12788081 .
  47. ↑ Chengjun Li, Iosef Cristiana, Jia Christina YH, Han Victor KM, Li Shawn Shun-Cheng: Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP / SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors . In: J. Biol. Chem. . 278, No. 6, United States, February 2003, ISSN  0021-9258 , pp. 3852-9. doi : 10.1074 / jbc.M206649200 . PMID 12458214 .
  48. ↑ Betty Chan, Lanyi Arpad, Song Hyun Kyu, Griesbach Jan, Simarro-Grande Maria, Poy Florence, Howie Duncan, Sumegi Janos, Terhorst Cox, Eck Michael J: SAP couples Fyn to SLAM immune receptors . In: Nat. Cell Biol . 5, No. 2, England, February 2003, ISSN  1465-7392 , pp. 155-60. doi : 10.1038 / ncb920 . PMID 12545174 .
  49. ^ A Marie-Cardine, Bruyns E, Eckerskorn C, Kirchgessner H, Meuer SC, Schraven B: Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes . In: J. Biol. Chem. . 272, No. 26, United States, June 1997, ISSN  0021-9258 , pp. 16077-80. doi : 10.1074 / jbc.272.26.16077 . PMID 9195899 .
  50. ↑ Liangtang Wu, Yu Zhenbao, Shen Shi-Hsiang: SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation . In: J. Biol. Chem. . 277, No. 43, United States, October 2002, ISSN  0021-9258 , pp. 40420-7. doi : 10.1074 / jbc.M206023200 . PMID 12171928 .
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  53. ↑ Chihiro Hisatsune, Kuroda Yukiko, Nakamura Kyoko, Inoue Takafumi, Nakamura Takeshi, Michikawa Takayuki, Mizutani Akihiro, Mikoshiba Katsuhiko: Regulation of TRPC6 channel activity by tyrosine phosphorylation . In: J. Biol. Chem. . 279, No. 18, United States, April 2004, ISSN  0021-9258 , pp. 18887-94. doi : 10.1074 / jbc.M311274200 . PMID 14761972 .
  54. ↑ S Uddin, Sher DA, Alsayed Y, Pons S, Colamonici OR, Fish EN, White MF, Platanias LC: Interaction of p59fyn with interferon-activated Jak kinases . In: Biochem. Biophys. Res. Commun. . 235, No. 1, United States, June 1997, ISSN  0006-291X , pp. 83-8. doi : 10.1006 / bbrc.1997.6741 . PMID 9196040 .
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  56. ↑ S Banin, Gout I, Brickell P: Interaction between Wiskott-Aldrich Syndrome protein (WASP) and the Fyn protein-tyrosine kinase . In: Mol Biol Rep... . 26, No. 3, August 1999, ISSN  0301-4851 , pp. 173-7. doi : 10.1023 / A: 1006954206151 . PMID 10532312 .
  57. ↑ OM Rivero-Lezcano, Marcilla A, Sameshima JH, Robbins KC: Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains . In: Mol. Cell. Biol . 15, No. 10, United States, October 1995, ISSN  0270-7306 , pp. 5725-31. PMID 7565724 . PMC 230823 (free full text).
  58. ↑ EN Neumeister, Zhu Y, Richard S, Terhorst C, Chan AC, Shaw AS: Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins . In: Mol. Cell. Biol . 15, No. 6, United States, June 1995, ISSN  0270-7306 , pp. 3171-8. PMID 7760813 . PMC 230549 (free full text).