GRIA 4

from Wikipedia, the free encyclopedia
Glutamate receptor, ionotrophic, AMPA 4
Properties of human protein
Mass / length primary structure 882 amino acids
Secondary to quaternary structure Homo- / heterotetramer, multipass membrane protein
Identifier
Gene name GRIA4
External IDs
Transporter classification
TCDB 1.A.10
designation glutamate-gated ion channel
Orthologue
human mouse
Entrez 2893 14802
Ensemble ENSG00000152578 ENSMUSG00000025892
UniProt P48058 Q8BXG8
Refseq (mRNA) NM_000829 NM_019691
Refseq (protein) NP_000820 NP_062665
Gene locus Chr 11: 104.99 - 105.36 Mb Chr 9: 4.42 - 4.8 Mb
PubMed search 2893 14802

The ionotropic glutamate receptor, AMPA 4 , also known as GRIA4 or GluR4 , is a human protein .

This membrane protein is a member of the glutamate-gated ion channels and mediates rapid excitatory signal transmission to synapses . The channel type knows AMPA as an agonist. The gene that codes for this protein is considered to be one of the many candidate genes for schizophrenia . For GRIA 4, mRNA variants generated by alternative splicing are known which code for different isoforms of the protein subunits.

See also

Recommended literature

  • McNamara JO, Eubanks JH, McPherson JD, et al. : Chromosomal localization of human glutamate receptor genes. in: J. Neurosci. vol. 12.7 pg. 2555-62 (1992) PMID 1319477
  • Hardy M, Younkin D, Tang CM, et al. : Expression of non-NMDA glutamate receptor channel genes by clonal human neurons. in: J. Neurochem. vol. 63.2 pg. 482-9 (1994) PMID 7518497
  • Roche KW, Raymond LA, Blackstone C, Huganir RL: Transmembrane topology of the glutamate receptor subunit GluR6. in: J. Biol. Chem. vol. 269.16 pg. 11679-82 (1994) PMID 8163463
  • Fletcher EJ, Nutt SL, Hoo KH, et al. : Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4. in: Recept. Channels vol. 3.1 pg. 21-31 (1996) PMID 8589990
  • Bonaldo MF, Lennon G, Soares MB: Normalization and subtraction: two approaches to facilitate gene discovery. in: Genome Res. vol. 6.9 pg. 791-806 (1997) PMID 8889548
  • Ripellino JA, Neve RL, Howe JR: Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum. in: Neuroscience vol. 82.2 pg. 485-97 (1998) PMID 9466455
  • Carvalho AL, Kameyama K, Huganir RL: Characterization of phosphorylation sites on the glutamate receptor 4 subunit of the AMPA receptors. in: J. Neurosci. vol. 19.12 pg. 4748-54 (1999) PMID 10366608
  • Chen L, Chetkovich DM, Petralia RS, et al. : Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. in: Nature vol. 408.6815 pg. 936-43 (2001) PMID 11140673
  • Hirbec H, Perestenko O, Nishimune A, et al. : The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. in: J. Biol. Chem. vol. 277.18 pg. 15221-4 (2002) PMID 11891216
  • Tomiyama M, Rodríguez-Puertas R, Cortés R, et al. : Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis. in: Synapse vol. 45.4 pg. 245-9 (2002) PMID 12125045
  • Pasternack A, Coleman SK, Jouppila A, et al. : Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain. in: J. Biol. Chem. vol. 277.51 pg. 49662-7 (2003) PMID 12393905
  • Correia SS, Duarte CB, Faro CJ, et al. : Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation. in: J. Biol. Chem. vol. 278.8 pg. 6307-13 (2003) PMID 12471040
  • Strausberg RL, Feingold EA, Grouse LH, et al. : Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. in: Proc. Natl. Acad. Sci. USA vol. 99.26 pg. 16899-903 (2003) PMID 12477932
  • Makino C, Fujii Y, Kikuta R, et al. : Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region. in: Am. J. Med. Genet. B Neuropsychiatr. Genet. vol. 116.1 pg. 17-22 (2003) PMID 12497607
  • Coleman SK, Cai C, Mottershead DG, et al. : Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4.1 protein. in: J. Neurosci. vol. 23.3 pg. 798-806 (2003) PMID 12574408
  • Pasternack A, Coleman SK, Féthière J, et al. : Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain. in: J. Neurochem. vol. 84.5 pg. 1184-92 (2003) PMID 12603841
  • Kawahara Y, Ito K, Sun H, et al. : GluR4c, an alternative splicing isoform of GluR4, is abundantly expressed in the adult human brain. in: Brain Res. Mol. Brain Res. vol. 127.1-2 pg. 150-5 (2004) PMID 15306133
  • Li G, Sheng Z, Huang Z, Niu L: Kinetic mechanism of channel opening of the GluRDflip AMPA receptor. in: Biochemistry vol. 44.15 pg. 5835-41 (2005) PMID 15823042
  • Nuriya M, Oh S, Huganir RL: Phosphorylation-dependent interactions of alpha-actinin-1 / IQGAP1 with the AMPA receptor subunit GluR4. in: J. Neurochem. vol. 95.2 pg. 544-52 (2005) PMID 16190873
  • Kimura K, Wakamatsu A, Suzuki Y, et al. : Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. in: Genome Res. vol. 16.1 pg. 55-65 (2006) PMID 16344560

Individual evidence

  1. ↑ a b Entrez Gene: GRIA4 glutamate receptor, ionotrophic, AMPA 4 . Retrieved December 31, 2010.