Bile Acid CoA: amino acid N-acyltransferase
Bile Acid CoA: amino acid N-acyltransferase | ||
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Properties of human protein | ||
Mass / length primary structure | 418 amino acids | |
Secondary to quaternary structure | Monomer | |
Identifier | ||
Gene name | BAAT | |
External IDs | ||
Enzyme classification | ||
EC, category | 3.1.2.2 , transferase | |
Response type | Transmission of cholic acid | |
Substrate | Choloyl-CoA + glycine / taurine | |
Products | Bile salts + CoA | |
Occurrence | ||
Parent taxon | multicellular animals |
The bile acid CoA: amino acid N-acyltransferase (BAT) is the enzyme in animals , the last step in the biosynthesis of bile salts catalyzed . Here is cholic or deoxycholic of CoA on amino acids transmitted in humans, these are up to 95% glycine or taurine . The reaction takes place in the peroxisomes of the liver cells ( hepatocytes ). The amidation increases the ability of the compounds to emulsify significantly, which means that lipids and vitamins can be better absorbed. Mutations in BAAT - gene are the cause of the rare Hypercholanämie (FHCA).
Catalyzed reactions
+ H 2 N-CH 2 -COO - ⇒ + CoA -SH
Choloyl-CoA reacts with glycinate to form glycocholate and CoA-SH. Equivalent to this, the reaction with taurate to taurocholate takes place.
Individual evidence
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Bile Acid Metabolism - Learning and Teaching Materials