UDP-glucose pyrophosphorylase
| UDP-glucose pyrophosphorylase | ||
|---|---|---|
|
||
| UDP-glucose pyrophosphorylase octamer, human according to PDB 4R7P | ||
| Properties of human protein | ||
| Mass / length primary structure | 507 amino acids | |
| Secondary to quaternary structure | Homooctamer | |
| Isoforms | 2 | |
| Identifier | ||
| Gene name | UGP2 | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 2.7.7.9 , nucleotidyl transferase | |
| Response type | Transmission of UDP | |
| Substrate | α-D-glucose-1-phosphate + UTP | |
| Products | UDP-glucose + pyrophosphate | |
| Occurrence | ||
| Parent taxon | Creature | |
UDP-glucose pyrophosphorylase (UGPase) (or UTP-glucose-1-phosphate-uridylyl transferase , gene : UGP2 ) is the name of the enzyme that catalyzes the conversion of UTP and glucose-1-phosphate to UDP-glucose . This reaction is part of several metabolic pathways in most living things. The previously suspected second homolog in humans with the gene UGP1 probably does not exist.
Catalyzed reaction
+ + PP i
UMP is transferred from UTP to glucose-1-phosphate, resulting in UDP-glucose and pyrophosphate. The reaction is part of glycogen synthesis , glycogen breakdown , galactose metabolism and uronic acid metabolism.
Individual evidence
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Glycogen Synthesis - Learning and Teaching Materials
Wikibooks: Biochemistry and Pathobiochemistry: Galactose Metabolism - Learning and Teaching Materials
Wikibooks: Biochemistry and Pathobiochemistry: Uronic Acid Metabolism - Learning and Teaching Materials