Glucose-1-phosphate

Structural formula
	Deprotonated form of α- D -glucose-1-phosphate
General
Surname	Glucose-1-phosphate
other names	Glc-1P; G1P; Cori ester; DISODIUM GLUCOSE PHOSPHATE ( INCI ) ;
Molecular formula	C 6 H 13 O 9 P
Brief description	Colorless solid (potassium salt)
External identifiers / databases
EC number	200-435-8
ECHA InfoCard	100,000,396
PubChem	65533
ChemSpider	58977
DrugBank	DB02843
Wikidata	Q418865
properties
Molar mass	260.14 g mol −1
safety instructions
GHS labeling of hazardous substances Potassium salt	no GHS pictograms
	no GHS pictograms
H and P phrases	H: no H-phrases
	P: no P-phrases
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

D - glucose-1-phosphate (also called Cori- ester ) is the form of D - glucose phosphorylated on carbon atom C1 and an isomer of D - glucose-6-phosphate . It plays an important role in many metabolic steps.

Biological importance

Glucose-1-phosphate is involved in various metabolic pathways. In the glycogen metabolism, it is formed from glycogen by phosphorolytic cleavage, which catalyzes a glycogen phosphorylase . Glucose-1-phosphate can be isomerized into glucose-6-phosphate for further processing by isomerization; this reaction is reversible and is catalyzed by a phosphoglucomutase . In addition, G1P is used for the biosynthesis of extracellular polysaccharides .

Another important reaction is the formation of UDP-glucose from α- D -glucose -1-phosphate and UTP by a UTP-glucose-1-phosphate uridyltransferase (GULT; UDP-glucose-phosphorylase EC 2.7.7.9 ):

{\ displaystyle \ mathrm {\ alpha {\ text {-Glc-1P}} + UTP \ {\ xrightarrow {GULT}} \ {\ text {UDP-Glc}} + PP_ {i}}}

UDP-glucose not only plays a role in glycogen metabolism, but also in galactose metabolism and uronic acid metabolism .

In addition to UTP, other nucleotides such as dTTP , ATP , CTP and GTP can also be linked with glucose-1-phosphate. These reactions are catalyzed by various transferases ( EC 2.7.7.24 , EC 2.7.7.27 , EC 2.7.7.33 or EC 2.7.7.34 ).

Individual evidence

↑ Entry on DISODIUM GLUCOSE PHOSPHATE in the CosIng database of the EU Commission, accessed on June 30, 2020.
↑ ^a ^b Data sheet α-D-Glucose 1-phosphate dipotassium salt hydrate, BioXtra, ≥98% from Sigma-Aldrich , accessed on February 15, 2013 ( PDF ).
↑ Dai, J. et al. (2006): Conformational cycling in beta-phosphoglucomutase catalysis: reorientation of the beta-D-glucose 1,6- (bis) phosphate intermediate . In: Biochemistry 45 (25); 7818-7824; PMID 16784233 ; doi : 10.1021 / bi060136v
↑ Jan Kolmann and Klaus-Heinrich Röhm: Pocket Atlas of Biochemistry . 3rd, completely revised and expanded edition 2003, Stuttgart, Georg Thieme Verlag, ISBN 978-3137594031 ; P. 156f.

[CosIng-1] Entry on DISODIUM GLUCOSE PHOSPHATE in the CosIng database of the EU Commission, accessed on June 30, 2020.

[Sigma-2] Data sheet α-D-Glucose 1-phosphate dipotassium salt hydrate, BioXtra, ≥98% from Sigma-Aldrich , accessed on February 15, 2013 ( PDF ).

[3] Dai, J. et al. (2006): Conformational cycling in beta-phosphoglucomutase catalysis: reorientation of the beta-D-glucose 1,6- (bis) phosphate intermediate . In: Biochemistry 45 (25); 7818-7824; PMID 16784233 ; doi : 10.1021 / bi060136v

[4] Jan Kolmann and Klaus-Heinrich Röhm: Pocket Atlas of Biochemistry . 3rd, completely revised and expanded edition 2003, Stuttgart, Georg Thieme Verlag, ISBN 978-3137594031 ; P. 156f.