Uridine triphosphate

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Structural formula
Structural formula of uridine triphosphate
General
Surname Uridine triphosphate
other names
  • UTP
  • [5- (2,4-dioxopyrimidin-1-yl) -3,4-dihydroxyoxolan-2-yl] methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate ( IUPAC )
  • [(2 R , 3 S , 4 R , 5 R ) -5- (2,4-dioxopyrimidin-1-yl) -3,4-dihydroxyoxolan-2-yl] methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate
Molecular formula C 9 H 15 N 2 O 15 P 3
External identifiers / databases
CAS number 63-39-8
EC number 200-558-7
ECHA InfoCard 100,000,508
PubChem 6133
DrugBank DB04005
Wikidata Q32904692
properties
Molar mass 484.14 g mol −1
safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Uridine triphosphate ( UTP ) is a nucleoside triphosphate with the base uracil . It is an RNA building block which is built into the RNA by splitting off two phosphate groups (pyrophosphate) and which serves as a coenzyme to activate sugars that are to be built into polysaccharides . To do this, it binds hexoses in the form of an ester , so that a UDP -hexose is formed.

The transesterification of UTP and glucose-1-phosphate to UDP-glucose and pyrophosphate activates the D- glucose for incorporation into glycogen polymers (excess sugar is stored as glycogen in animals). This process is catalyzed by the enzyme glucose-1-phosphate UTP transferase .

When D - galactose is isomerized to glucose, UDP-galactose is initially formed, which is then converted into UDP-glucose. Your UDP forwards this to the next galactose.

See also

Other ribonucleoside triphosphates :

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ↑ Georg Löffler, Petro E. Petrides, Peter C. Heinrich (Eds.): Biochemistry and Pathobiochemistry . 8., completely reworked. Edition. Springer, Berlin, Heidelberg 2007, ISBN 978-3-540-32680-9 , pp. 369 .