Guanine deaminase
| Guanine deaminase | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 454 amino acids | |
| Secondary to quaternary structure | Homodimer | |
| Cofactor | Zn 2+ | |
| Isoforms | 3 | |
| Identifier | ||
| Gene name | GDA | |
| External IDs |
|
|
| Enzyme classification | ||
| EC, category | 3.5.4.3 , hydrolase | |
| Response type | Amine hydrolysis | |
| Substrate | Guanine + H 2 O | |
| Products | Xanthine + NH 3 | |
| Occurrence | ||
| Parent taxon | Creature | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 9615 | 14544 |
| Ensemble | ENSG00000119125 | ENSMUSG00000058624 |
| UniProt | Q9Y2T3 | Q9R111 |
| Refseq (mRNA) | NM_001242505 | NM_010266 |
| Refseq (protein) | NP_001229434 | NP_034396 |
| Gene locus | Chr 9: 72.11 - 72.26 Mb | Chr 19: 21.39 - 21.47 Mb |
| PubMed search | 9615 |
14544
|
The guanine deaminase is the enzyme that the deamination of guanine to xanthine catalyzed . This reaction step, which occurs in all living things, leads to the breakdown of guanine, which in humans ends with uric acid after the next step .
A splice variant of guanine deaminase called cypine is involved in the development of the nervous system; it has a function in regulating the branching of dendritic cells . Increased cypin expression is triggered by the growth factor BDNF . In the liver, the GDA value is increased when there is damage.
The catalyzed reaction:
+ H 2 O + NH 3 
Guanine is deaminated and xanthine is produced.
Individual evidence
- ↑ UniProt Q9Y2T3
- ↑ JR Fernández, B. Byrne, BL Firestein: Phylogenetic analysis and molecular evolution of guanine deaminases: from guanine to dendrites. In: Journal of molecular evolution. Volume 68, Number 3, March 2009, pp. 227-235, ISSN 1432-1432 . doi : 10.1007 / s00239-009-9205-x . PMID 19221682 .
- ↑ M. Kwon, JR Fernández et al. a .: BDNF-promoted increases in proximal dendrites occur via CREB-dependent transcriptional regulation of cypin. In: The Journal of neuroscience: the official journal of the Society for Neuroscience. Volume 31, Number 26, June 2011, pp. 9735-9745, ISSN 1529-2401 . doi : 10.1523 / JNEUROSCI.6785-10.2011 . PMID 21715638 . PMC 3139247 (free full text).
- ↑ P. Li, S. Xu et al. a .: [The value of determining guanine deaminase in diagnosis of hepatic diseases]. In: Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao / [bian ji zhe, Hua xi yi ke da xue xue bao bian wei hui]. Volume 27, Number 2, June 1996, pp. 189-191, ISSN 0257-7712 . PMID 9389040 .
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Purine Metabolism - Learning and Teaching Materials
