Human herpes virus 7

Human herpes virus 7
Systematics
Classification : Viruses Area : Duplodnaviria Empire : Heunggongvirae Phylum : Peploviricota Class : Herviviricetes Order : Herpes viral Family : Herpesviridae Subfamily : Betaherpesvirinae Genre : Roseolovirus Type : Human herpes virus 7
Scientific name
Human beta herpesvirus 7 , 6B
Short name
HHV-7
Left
NCBI  Taxonomy: 10372 ICTV Taxon History: 201851474

The human herpes virus 7 (HHV-7) is a herpesvirus which the subfamily of the beta herpes viruses belongs.

meaning

Infection with HHV-7 usually occurs in childhood as an asymptomatic infection or as an exanthema subitum . This is followed by a lifelong latency of the virus in the body. In adolescence at the latest, an infection rate of around 95% is assumed. Reactivations are particularly problematic in immunosuppressed patients, for example after organ transplants. In addition, reactivations of HHV-7, as well as reactivations of the related human herpesvirus 6 (HHV-6) , are discussed as triggers of the skin disease pityriasis rosea .

Further associations of HHV-7 were found in various other clinical pictures, although the clinical significance of the infection is often unclear. In children and immunocompromised adults with diseases of the central nervous system , HHV-7 can in some cases be detected in the cerebrospinal fluid . In exacerbations of interstitial lung diseases , HHV-7 can be detected in nasal secretions, sputum or in the bronchoalveolar lavage . There is also evidence that HHV-7 is a contributory factor in myocarditis in children.

Diagnosis

The diagnosis can be carried out serologically or by means of PCR . Serological diagnostics using ELISA or immunofluorescence are considered less specific, as cross-reactivity with HHV-6 and CMV can occur here. The PCR detection, however, is specific and highly sensitive.

therapy

Treatment of the infection with HHV-7 is usually not necessary and is only carried out in immunosuppressed patients. The antiviral agent ganciclovir appears to be able to lower the viral load of HHV-7. The active ingredients foscarnet and cidofovir are also used for therapy.

Individual evidence

1. ↑ ^{a b c d e} ICTV: ICTV Taxonomy history: Human alphaherpesvirus 1 , EC 51, Berlin, Germany, July 2019; Email ratification March 2020 (MSL # 35)
2. ↑ ^{a b c d} Other herpesviruses: HHV-6, HHV-7, HHV-8, HSV-1 and -2, VZV. In: Am J Transplant. No. 4 Suppl 10, Nov 2004, pp. 66-71.
3. ↑ ^{a b} Virology of the Rostock University Medical Center: Human herpes virus types 6 and 7 (HHV-6, HHV-7) . (PDF) Retrieved April 7, 2018 . 
4. ^ A. Rebora, F. Drago, F. Broccolo: Pityriasis rosea and herpesviruses: Facts and controversies. In: Clin Dermatol. Volume 28, No. 5, Sep-Oct 2010, pp. 497-501.
5. ↑ Í. Corral, S. Sainz de la Maza, M. Rodríguez, MM Kawiorski, MJ López-Martínez, JC Galán: Molecular detection of human herpesvirus 7 DNA in cerebrospinal fluid from adult patients with neurological disorders. In: J Neurovirol. 13 Mar 2018.
6. ↑ T. Saraya, H. Kimura, D. Kurai, M. Tamura, Y. Ogawa, S. Mikura, M. Sada, M. Oda, T. Watanabe, K. Ohkuma, M. Inoue, K. Honda, M Watanabe, T. Yokoyama, M. Fujiwara, H. Ishii, H. Takizawa: Clinical significance of respiratory virus detection in patients with acute exacerbation of interstitial lung diseases. In: Respir Med. Volume 136, Mar 2018, pp. 88-92.
7. ↑ R. Ozdemir, M. Kucuk, SE Dibeklioglu: Report of a myocarditis Outbreak among Pediatric Patients: Human herpesvirus 7 as a Causative Agent? In: J Trop Pediatr. 30th Nov 2017.
8. ^ Institute for Medical Microbiology at the University Hospital Münster: Virus: Human Herpesvirus 7 (HHV-7). Retrieved April 7, 2018 . 

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !