Foscarnet

Structural formula
General
Non-proprietary name	Foscarnet
other names	Phosphonoformic acid
Molecular formula	CH 3 O 5 P
External identifiers / databases
PubChem	3415
ChemSpider	3297
DrugBank	DB00529
Wikidata	Q420387
Drug information
ATC code	J05 AD01
Drug class	Antiviral
Mechanism of action	DNA polymerase inhibitor
properties
Molar mass	126.01 g · mol -1
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances Caution
H and P phrases	H: 315-319-335
	P: 261-305 + 351 + 338
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Foscarnet is an antiviral drug ( antiviral ) that is mainly used to treat herpes viruses in the presence of resistance to other antivirals. The spectrum of activity includes the cytomegalovirus , the herpes simplex virus and the varicella zoster virus . Foscarnet is sold as the sodium salt under the brand names Foscavir ^® (CH) and Triapten ^® (D) and is subject to medical prescription .

pharmacology

application areas

Foscarnet is approved for the systemic treatment of a life- and eye-light-threatening disease caused by cytomegaloviruses and for the treatment of acute mucosal infections caused by aciclovir-resistant herpes viruses in patients with AIDS . Foscarnet is also used as an alternative in the case of herpes simplex encephalitis in the case of existing aciclovir resistance. The application is intravenous. The half-life in the blood is 3.3–6.8 hours. In addition, Foscarnet can be used locally for the treatment of skin and mucous membrane infections caused by herpes simplex virus types 1 and 2, such as herpes labialis , herpes genitalis and herpes integumentalis .

Mechanism of action

Foscarnet is an analogue of pyrophosphate . As such, it blocks the pyrophosphate binding site of DNA polymerase and reverse transcriptase and is thus a selective inhibitor of these viral enzymes .

Side effects

Individual evidence

↑ ^a ^b Data sheet Sodium phosphonoformate tribasic hexahydrate from Sigma-Aldrich , accessed on November 7, 2016 ( PDF ).
↑ External identifiers of or database links to Foscarnet trisodium anhydrate : CAS number: 63585-09-1, EC number: 695-653-7, ECHA -InfoCard: 100.224.300 , PubChem : 44561 , ChemSpider : 40540 , DrugBank : DBSALT000200 , Wikidata : Q27225687 .

[Sigma-1] Data sheet Sodium phosphonoformate tribasic hexahydrate from Sigma-Aldrich , accessed on November 7, 2016 ( PDF ).

[2] External identifiers of or database links to Foscarnet trisodium anhydrate : CAS number: 63585-09-1, EC number: 695-653-7, ECHA -InfoCard: 100.224.300 , PubChem : 44561 , ChemSpider : 40540 , DrugBank : DBSALT000200 , Wikidata : Q27225687 .