Foscarnet
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Non-proprietary name | Foscarnet | |||||||||||||||
other names |
Phosphonoformic acid |
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Molecular formula | CH 3 O 5 P | |||||||||||||||
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properties | ||||||||||||||||
Molar mass | 126.01 g · mol -1 | |||||||||||||||
safety instructions | ||||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Foscarnet is an antiviral drug ( antiviral ) that is mainly used to treat herpes viruses in the presence of resistance to other antivirals. The spectrum of activity includes the cytomegalovirus , the herpes simplex virus and the varicella zoster virus . Foscarnet is sold as the sodium salt under the brand names Foscavir ® (CH) and Triapten ® (D) and is subject to medical prescription .
pharmacology
application areas
Foscarnet is approved for the systemic treatment of a life- and eye-light-threatening disease caused by cytomegaloviruses and for the treatment of acute mucosal infections caused by aciclovir-resistant herpes viruses in patients with AIDS . Foscarnet is also used as an alternative in the case of herpes simplex encephalitis in the case of existing aciclovir resistance. The application is intravenous. The half-life in the blood is 3.3–6.8 hours. In addition, Foscarnet can be used locally for the treatment of skin and mucous membrane infections caused by herpes simplex virus types 1 and 2, such as herpes labialis , herpes genitalis and herpes integumentalis .
Mechanism of action
Foscarnet is an analogue of pyrophosphate . As such, it blocks the pyrophosphate binding site of DNA polymerase and reverse transcriptase and is thus a selective inhibitor of these viral enzymes .
Side effects
Individual evidence
- ↑ a b Data sheet Sodium phosphonoformate tribasic hexahydrate from Sigma-Aldrich , accessed on November 7, 2016 ( PDF ).
- ↑ External identifiers of or database links to Foscarnet trisodium anhydrate : CAS number: 63585-09-1, EC number: 695-653-7, ECHA -InfoCard: 100.224.300 , PubChem : 44561 , ChemSpider : 40540 , DrugBank : DBSALT000200 , Wikidata : Q27225687 .