Helmut Drexler (doctor)

Helmut Drexler

Helmut Drexler (born on February 24, 1951 in Karlsruhe ; died on September 13, 2009 in Hanover ) was a German doctor and scientist. Since 1996 he has been director and professor of the Clinic for Cardiology and Angiology at the Hannover Medical School (MHH). As a clinician scientist (researching and teaching doctor), he has significantly influenced the translational integration of molecular methods in clinical cardiology.

Life

Drexler studied human medicine at the University of Freiburg from 1970 to 1976. After completing his doctorate, he began training as an assistant doctor in 1977 at the Institute for Pathology ( Walter Sandritter ) and subsequently in 1978 at the Medical Clinic III for Cardiology and Angiology at the University of Freiburg ( Hanjörg Just ).

A post-doctoral fellowship from the German Research Foundation (DFG) led him to Penn State University / USA (Robert Zelis) from 1981–83. In 1986 he qualified as a professor for internal medicine at the University of Freiburg. As part of a Heisenberg grant from the DFG, Drexler worked in research and clinic as a visiting professor at Stanford University in Palo Alto / USA (Victor Dzau) in 1991/92 .

science

His main research area was the mechanisms of heart failure and coronary artery disease. In this context, he has spent many years studying the pathophysiology of the renin-angiotensin system and endothelial function. Together with his team, he carried out fundamental studies on the molecular clarification of postpartum cardiomyopathy, published in Cell, and the first randomized multicenter study (BOOST trial) on the importance of intracoronary stem cell therapy in patients with acute myocardial infarction. He acted as principal investigator and national coordinator of numerous international multicenter randomized studies in the field of cardiology (including ACE inhibitors, ATII blockers).

Contributions

In addition to numerous publications of his own in national and international journals as well as book contributions, Drexler was a reviewer and member of various editorial boards (including the European Heart Journal , Circulation , Circulation Research , American College of Cardiology, etc.). Shortly before his death, he was appointed European editor of Circulation.

Helmut Drexler was the spokesman for the Clinical Research Group of the German Research Foundation (DFG) on the topic of "Control mechanisms of cardiac adaptation and regeneration", was the European coordinator of the transatlantic LEDUQC foundation and founder of the REBIRTH cluster of excellence of the integrated science and treatment center for transplantation at the Hannover Medical School.

Private

Helmut Drexler was married and had one daughter.

Individual evidence

↑ B. Schieffer, T. Münzel, H.-P. Schultheiss: Obituary for the death of Professor Dr. med. Helmut Drexler . In: The cardiologist . tape 3 , no. 6 , November 5, 2009, ISSN 1864-9726 , p. 519 , doi : 10.1007 / s12181-009-0233-y .
^ Victor J. Dzau, Jeffery D. Molkentin: Helmut Drexler, MD: 1951–2009 . In: Circulation . tape 120 , no. 23 , December 8, 2009, ISSN 0009-7322 , p. 2402–2403 , doi : 10.1161 / CIRCULATIONAHA.109.917120 ( ahajournals.org [accessed June 22, 2019]).
↑ Münzel T, Kurz S, Holtz J, Busse R, Steinhauer H: Neurohormonal inhibition and hemodynamic unloading during prolonged inhibition of ANF degradation in patients with severe chronic heart failure. In: Circulation . tape 86 , no. 4 , October 1, 1992, p. 1089-1098 , doi : 10.1161 / 01.CIR.86.4.1089 ( ahajournals.org [accessed June 22, 2019]).
↑ Schieffer Bernhard, Schieffer Elisabeth, Hilfiker-Kleiner Denise, Hilfiker Andres, Kovanen Petri T .: Expression of Angiotensin II and Interleukin 6 in Human Coronary Atherosclerotic Plaques . In: Circulation . tape 101 , no. 12 , March 28, 2000, pp. 1372–1378 , doi : 10.1161 / 01.CIR.101.12.1372 ( ahajournals.org [accessed June 22, 2019]).
^ H Drexler, AM Zeiher, K Meinzer, H Just: Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine . In: The Lancet . tape 338 , no. 8782-8783 , December 1991, pp. 1546–1550 , doi : 10.1016 / 0140-6736 (91) 92372-9 ( elsevier.com [accessed June 22, 2019]).
↑ Denise Hilfiker-Kleiner, Karol Kaminski, Edith Podewski, Tomasz Bonda, Arnd Schaefer: A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy . In: Cell . tape 128 , no. 3 , February 2007, p. 589–600 , doi : 10.1016 / j.cell.2006.12.036 ( elsevier.com [accessed June 22, 2019]).
↑ Kai C Wollert, Gerd P Meyer, Joachim Lotz, Stefanie Ringes Lichtenberg, Peter Lippolt: Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomized controlled clinical trial . In: The Lancet . tape 364 , no. 9429 , July 2004, p. 141–148 , doi : 10.1016 / S0140-6736 (04) 16626-9 ( elsevier.com [accessed June 22, 2019]).

personal data
SURNAME	Drexler, Helmut
BRIEF DESCRIPTION	German cardiologist and university professor
DATE OF BIRTH	February 24, 1951
PLACE OF BIRTH	Karlsruhe
DATE OF DEATH	September 13, 2009
Place of death	Hanover

[1] B. Schieffer, T. Münzel, H.-P. Schultheiss: Obituary for the death of Professor Dr. med. Helmut Drexler . In: The cardiologist . tape 3 , no. 6 , November 5, 2009, ISSN 1864-9726 , p. 519 , doi : 10.1007 / s12181-009-0233-y .

[2] Victor J. Dzau, Jeffery D. Molkentin: Helmut Drexler, MD: 1951–2009 . In: Circulation . tape 120 , no. 23 , December 8, 2009, ISSN 0009-7322 , p. 2402–2403 , doi : 10.1161 / CIRCULATIONAHA.109.917120 ( ahajournals.org [accessed June 22, 2019]).

[3] Münzel T, Kurz S, Holtz J, Busse R, Steinhauer H: Neurohormonal inhibition and hemodynamic unloading during prolonged inhibition of ANF degradation in patients with severe chronic heart failure. In: Circulation . tape 86 , no. 4 , October 1, 1992, p. 1089-1098 , doi : 10.1161 / 01.CIR.86.4.1089 ( ahajournals.org [accessed June 22, 2019]).

[4] Schieffer Bernhard, Schieffer Elisabeth, Hilfiker-Kleiner Denise, Hilfiker Andres, Kovanen Petri T .: Expression of Angiotensin II and Interleukin 6 in Human Coronary Atherosclerotic Plaques . In: Circulation . tape 101 , no. 12 , March 28, 2000, pp. 1372–1378 , doi : 10.1161 / 01.CIR.101.12.1372 ( ahajournals.org [accessed June 22, 2019]).

[5] H Drexler, AM Zeiher, K Meinzer, H Just: Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine . In: The Lancet . tape 338 , no. 8782-8783 , December 1991, pp. 1546–1550 , doi : 10.1016 / 0140-6736 (91) 92372-9 ( elsevier.com [accessed June 22, 2019]).

[6] Denise Hilfiker-Kleiner, Karol Kaminski, Edith Podewski, Tomasz Bonda, Arnd Schaefer: A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy . In: Cell . tape 128 , no. 3 , February 2007, p. 589–600 , doi : 10.1016 / j.cell.2006.12.036 ( elsevier.com [accessed June 22, 2019]).

[7] Kai C Wollert, Gerd P Meyer, Joachim Lotz, Stefanie Ringes Lichtenberg, Peter Lippolt: Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomized controlled clinical trial . In: The Lancet . tape 364 , no. 9429 , July 2004, p. 141–148 , doi : 10.1016 / S0140-6736 (04) 16626-9 ( elsevier.com [accessed June 22, 2019]).