Insulysin

Insulysin
	Existing structure data: 2G47 , 2G48 , 2G49 , 2G54 , 2G56 , 2JBU , 2JG4 , 2WBY , 2WC0 , 2WK3 , 2YPU , 3CWW , 3E4A , 3E4Z , 3E50 , 3H44 , 3HGZ , 3N56 , 3N57 , 3OFI , 3QZ2 , 4DTT , 4DWK , 4GS8 , 4GSC , 4GSF , 4IFH , 4IOF , 4LTE , 4M1C , 4Q5Z , 4QIA , 4RAL
Properties of human protein
Mass / length primary structure	1018 amino acids
Secondary to quaternary structure	Dimer; Oligomer
Cofactor	Zn 2+
Identifier
Gene name	IDE
External IDs	OMIM : 146680 ; UniProt : P14735 ; MGI : 96412 ;
Enzyme classification
EC, category	3.4.24.56 , metalloprotease
MEROPS	M16.002
Response type	Highly specific hydrolysis
Substrate	insulin
Products	Degradation products
Occurrence
Parent taxon	Eukaryotes , bacteria
	Orthologue

Insulysin (IDE) (also: insulin-degrading enzyme , previously: insulinase ) is an enzyme that occurs in bacteria and eukaryotes . In vertebrates, IDE is able to break down , in addition to the protein insulin, several other extracellular proteins such as beta-amyloid and somatostatin and thus render them harmless. IDE is expressed in all tissue types in humans.

Studies in Han Chinese, German and Muscovites suggest an association of polymorphisms in the IDE - gene with the formation of a metabolic syndrome and diabetes mellitus type 2. Furthermore, low levels of expression of IDE statistically with the occurrence of Alzheimer's disease , respectively. Insulysin is also a gateway for infection with the varicella zoster virus .

Individual evidence

↑ Homologues at OMA
↑ UniProt P14735
↑ Ciaccio C, Tundo GR, Grasso G, et al. : Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity . In: J. Mol. Biol. . 385, No. 5, February 2009, pp. 1556-67. doi : 10.1016 / j.jmb.2008.11.025 . PMID 19073193 .
↑ Lu X, Huang Y, Liu Y, Wu X, Shi X: Variants in the insulin-degrading enzyme gene are associated with metabolic syndrome in Chinese elders . In: Metab. Clin. Exp. . 58, No. 10, October 2009, pp. 1465-9. doi : 10.1016 / j.metabol.2009.04.027 . PMID 19592050 .
↑ Rudovich N, Pivovarova O, Fisher E, et al. : Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes . In: J Mol Med . October 2009. doi : 10.1007 / s00109-009-0540-6 . PMID 19809796 .
↑ Slominsky PA, Pivovarova OV, Shadrina MI, et al .: Association of insulinase gene polymorphisms with type 2 diabetes mellitus in patients from the Moscow population . In: Russian Journal of Genetics . 45, No. 1, January 2009, pp. 113-7. doi : 10.1134 / S1022795409010165 .
↑ Ali MA, Li Q, Fischer ER, Cohen JI: The insulin degrading enzyme binding domain of varicella-zoster virus (VZV) glycoprotein E is important for cell-to-cell spread and VZV infectivity, while a glycoprotein I binding domain is essential for infection . In: Virology . 386, No. 2, April 2009, pp. 270-9. doi : 10.1016 / j.virol.2009.01.023 . PMID 19233447 .
↑ Zuo X, Jia J: Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease . In: Brain Res. . 1249, January 2009, pp. 1-8. doi : 10.1016 / j.brainres.2008.10.034 . PMID 18996360 .
↑ de Tullio MB, Morelli L, Castaño EM: The irreversible binding of amyloid peptide substrates to insulin-degrading enzyme: a biological perspective . In: Prion . 2, No. 2, April 2008, pp. 51-6. PMID 19098445 . PMC 2634517 (free full text).

[1] Homologues at OMA

[2] UniProt P14735

[3] Ciaccio C, Tundo GR, Grasso G, et al. : Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity . In: J. Mol. Biol. . 385, No. 5, February 2009, pp. 1556-67. doi : 10.1016 / j.jmb.2008.11.025 . PMID 19073193 .

[4] Lu X, Huang Y, Liu Y, Wu X, Shi X: Variants in the insulin-degrading enzyme gene are associated with metabolic syndrome in Chinese elders . In: Metab. Clin. Exp. . 58, No. 10, October 2009, pp. 1465-9. doi : 10.1016 / j.metabol.2009.04.027 . PMID 19592050 .

[5] Rudovich N, Pivovarova O, Fisher E, et al. : Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes . In: J Mol Med . October 2009. doi : 10.1007 / s00109-009-0540-6 . PMID 19809796 .

[6] Slominsky PA, Pivovarova OV, Shadrina MI, et al .: Association of insulinase gene polymorphisms with type 2 diabetes mellitus in patients from the Moscow population . In: Russian Journal of Genetics . 45, No. 1, January 2009, pp. 113-7. doi : 10.1134 / S1022795409010165 .

[7] Ali MA, Li Q, Fischer ER, Cohen JI: The insulin degrading enzyme binding domain of varicella-zoster virus (VZV) glycoprotein E is important for cell-to-cell spread and VZV infectivity, while a glycoprotein I binding domain is essential for infection . In: Virology . 386, No. 2, April 2009, pp. 270-9. doi : 10.1016 / j.virol.2009.01.023 . PMID 19233447 .

[8] Zuo X, Jia J: Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease . In: Brain Res. . 1249, January 2009, pp. 1-8. doi : 10.1016 / j.brainres.2008.10.034 . PMID 18996360 .

[9] Tullio MB, Morelli L, Castaño EM: The irreversible binding of amyloid peptide substrates to insulin-degrading enzyme: a biological perspective . In: Prion . 2, No. 2, April 2008, pp. 51-6. PMID 19098445 . PMC 2634517 (free full text).