John Edgar Dick
John Edgar Dick (* 1954 ) is a Canadian molecular biologist, molecular geneticist and cancer researcher, known for research on cancer - stem cells .
John Dick studied microbiology at the University of Manitoba and received his PhD in 1984. He was a postdoctoral fellow with Alan Bernstein in Toronto at the Ontario Cancer Institute , where he began studying leukemia and cancer research, and at the Mt. Sinai Hospital Research Institute. He is a professor at the University of Toronto and a researcher at the University Health Network in Toronto and the Princess Margaret Cancer Center . He has a Canada Research Chair in stem cell biology.
He was the first to identify cancer stem cells in the mid-1990s. These were cancer stem cells in special forms of human leukemia (leukemic stem cells, LSC, in contrast to normal blood stem cells HSC). With the discovery, he also showed that there are significant differences among cancer cells.
As a post-doc, Dick developed a technique with which mice with defective immune systems (SCID, Severe combined immunodeficiency) tolerate and reproduce human blood cells, which made him internationally known. The mouse model is also known as the in vivo repopulation assay or the in vivo stem cell assay . Dick created a form of human leukemia ( acute myeloid leukemia , AML) in a (SCID) mouse and showed that human blood stem cells can repopulate the bone marrow in NOD / SCID mice. According to Dick, chemotherapeutic agents in cancer treatment primarily kill rapidly growing cells and relapse occurs if the cancer stem cells are not all destroyed. In 1997 he discovered cancer stem cells in three other types of leukemia and formulated his cancer stem cell hypothesis according to which there is a hierarchy of cancer cells with the abnormal stem cell at the base. If this is missing, the tumor cannot grow.
He is a Fellow of the Royal Society of Canada (2004) and the Royal Society (2014). In 2000 he received the Robert L. Noble Prize , in 2002 the Boerhaave Medal from the University of Leiden and in 2017 the Keio Medical Science Prize . He is a fellow of the American Association for Cancer Research .
Web links
Individual evidence
- ↑ Date of birth according to Rigshospital Copenhagen, International KFJ Award for Dick 2017
- ^ Biography of Dick at the Royal Society
- ↑ T. Lapidot, Dick et al. a .: A cell initiating human acute myeloid leukaemia after transplantation into SCID mice, Nature, Volume 367, 1994, pp. 645-648
- ↑ A. Larochelle, Dick et al. a .: Identification of primitive human hematopoietic cells capable of repopulating NOD / SCID mouse bone marrow: Implications for gene therapy, Nature Medicine, Volume 2, 1996, pp. 1329-1337
- ↑ Website about him at the AACR
| personal data | |
|---|---|
| SURNAME | Dick, John Edgar |
| BRIEF DESCRIPTION | Canadian cell and molecular biologist |
| DATE OF BIRTH | 1954 |