John P. Morrissey

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John Patrick Morrissey (born December 31, 1968 in Cork , Ireland ) is an Irish microbiologist and biotechnologist . Since 2000 he has been working and teaching as professor of microbiology at University College Cork . He mainly works on the optimization of yeasts for industrial biotechnology , but also deals with numerous other organisms.

life and work

John Morrissey studied microbiology at University College Cork, graduating in 1990 with a Bachelor of Science degree. After graduating, he moved to the European Molecular Biology Laboratory (EMBL) in Heidelberg , where he worked in David Tollervey's group on his doctoral thesis in the field of yeast molecular biology, especially on specific snoRNA and the formation of rRNA in baker's yeast ( Saccharomyces cerevisiae ). He received his PhD for his work in 1994 and was a postdoctoral fellow at the University of California, Berkeley , in the United States from 1995 to 1997 .

From 1998 to 2000 he worked and researched at the John Innes Center (JIC) in Norwich, England, and dealt with resistance of fungi to antibiotics and natural fungicides produced by plants . He continued this work after moving to University College Cork in 2000, where he mainly worked with the microbiologist Fergal O'Gara to investigate the interactions of root bacteria with their host plants and their fungicidal properties. Since 2003, Morrissey has headed his own research group as professor of microbiology at the UCC, whose research focus initially continued with previous work. Morrissey continued to investigate the ecological relationships of bacteria in the root system of plants, the fungicidal effects of root-associated Pseudomonas species and their potential use in environmental biotechnology, as well as general biochemical relationships between bacteria and fungi. From 2010, Morrissey also dealt with the biotechnological use and metagenomics of marine organisms, especially sponges (Porifera), on which he also wrote several book chapters.

His current focus is on the molecular biology and microecology of yeast as well as the use of genetically adapted yeast cells for industrial biotechnology. Morrissey focuses primarily on the use of Kluyveromyces marxianus . Among other projects, he heads the European research projects YEASTCELL (until 2017), YEASTDOC and CHASSY with a focus on yeasts as production organisms.

Awards and functions

John P. Morrissey serves on the editorial board of FEMS Yeast Research . He is also a member and representative for Ireland of the International Commission on Yeasts (ICY) and was elected chairman of the eukaryotes section of the Society for General Microbiology (SGM) from 2013 to 2017 . He is also a member of the board of the Microbial Physiology Section of the European Federation of Biotechnology .

Publications (selection)

John P. Morrissey regularly publishes articles on his research in academic journals. These are contributions from original research as well as reviews of central topics in molecular biology and biotechnology, including:

  • Yves Henry, Heather Wood, John P. Morrissey, Elisabeth Petfalski, Stephen Kearsey, David Tollervey: The 5 ′ end of yeast 5.8 S rRNA is generated by exonucleases from an upstream cleavage site. The EMBO journal 13 (10), 1994; Pp. 2452-2463. ( Full text )
  • John P. Morrissey, Anne E. Osbourn: Fungal Resistance to Plant Antibiotics as a Mechanism of Pathogenesis. Microbiology and Molecular Biology Reviews 63 (3), September 1999; Pp. 708-724.
  • Ultan F. Walsh, John P. Morrissey, Fergal O'Gara: Pseudomonas for biocontrol of phytopathogens: from functional genomics to commercial exploitation. Current Opinion in Biotechnology 12 (3), 2001; Pp. 289-295. doi : 10.1016 / S0958-1669 (00) 00212-3
  • MM Lane, JP Morrissey: Kluyveromyces marxianus : A yeast emerging from its sister's shadow. Fungal Biology Reviews 24 (1), 2010; Pp. 17-26. doi : 10.1016 / j.fbr.2010.01.001
  • Jonathan Kennedy, Burkhardt Flemer, Stephen A. Jackson, David PH Lejon, John P. Morrissey, Fergal O'Gara, Alan DW Dobson: Marine metagenomics: new tools for the study and exploitation of marine microbial metabolism. Marine Drugs 8 (3), 2010; Pp. 608-628. doi : 10.3390 / md8030608
  • Leonie Baumann, Arun S. Rajkumar, John P. Morrissey, Eckhard Boles , Mislav Oreb: A Yeast-Based Biosensor for Screening of Short- and Medium-Chain Fatty Acid Production. ACS Synthetic Biology 7 (11), 2018; pp 2640-2646. doi : 10.1021 / acssynbio.8b00309 .

supporting documents

  1. ↑ John P. Morrissey, David Tollervey: Yeast snR30 is a small nucleolar RNA required for 18S rRNA synthesis. Molecular and Cellular Biology 13 (4), 1994; Pp. 2469-2477. ( Full text ).
  2. ↑ Yves Henry, Heather Wood, John P. Morrissey, Elisabeth Petfalski, Stephen Kearsey, David Tollervey: The 5 ′ end of yeast 5.8 S rRNA is generated by exonucleases from an upstream cleavage site. The EMBO journal 13 (10), 1994; Pp. 2452-2463. ( Full text ).
  3. ↑ John P. Morrissey, David Tollervey: Birth of the snoRNPs: the evolution of RNase MRP and the eukaryotic pre-rRNA processing system. Trends in Biochemical Sciences 20 (2), 1995; Pp. 78-82. doi : 10.1016 / S0968-0004 (00) 88962-8 .
  4. ↑ a b c John Morrissey , University College Cork biography; accessed on March 29, 2019.
  5. ↑ John P. Morrissey, Anne E. Osbourn: Fungal Resistance to Plant Antibiotics as a Mechanism of Pathogenesis. Microbiology and Molecular Biology Reviews 63 (3), September 1999; Pp. 708-724. ( Full text )
  6. ↑ Ultan F Walsh, John P Morrissey, Fergal O'Gara: Pseudomonas for biocontrol of phytopathogens: from functional genomics to commercial exploitation. Current Opinion in Biotechnology 12 (3), 2001; Pp. 289-295. doi : 10.1016 / S0958-1669 (00) 00212-3 , full text .
  7. ↑ G. Louise Mark, J. Maxwell Dow, Patrick D. Kiely, Hazel Higgins, Jill Haynes, Christine Baysse, Abdelhamid Abbas, Tara Foley, Ashley Franks, John Morrissey, Fergal O'Gara: Transcriptome profiling of bacterial responses to root exudates identifies genes involved in microbe-plant interactions. Proceedings of the National Academy of Sciences 102 (48), 2005; Pp. 17454-17459. doi : 10.1073 / pnas.0506407102 .
  8. ↑ Genevieve L. Mark, John P. Morrissey, P. Higgins, Fergal O'Gara: Molecular-based strategies to exploit Pseudomonas biocontrol strains for environmental biotechnology applications. FEMS Microbiology Ecology 56 (2), 2006; Pp. 167-177. doi : 10.1111 / j.1574-6941.2006.00056.x .
  9. ↑ Gordon McAlester, Fergal O'Gara, John P Morrissey: Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans. Journal of medical microbiology 57 (5), 2008; Pp. 563-569. doi : 10.1099 / jmm.0.47705-0 .
  10. ↑ Jonathan Kennedy, Burkhardt Flemer, Stephen A Jackson, David PH Lejon, John P Morrissey, Fergal O'gara, Alan DW Dobson: Marine metagenomics: new tools for the study and exploitation of marine microbial metabolism. Marine Drugs 8 (3), 2010; Pp. 608-628. doi : 10.3390 / md8030608 .
  11. ↑ PW Baker, J. Kennedy, J. Morrissey, Fergal O'Gara, ADW Dobson, Julian Roberto Marchesi: Endoglucanase activities and growth of marine ‐ derived fungi isolated from the sponge Haliclona simulans. Journal of Applied Microbiology 108 (5), 2010; Pp. 1668-1675. doi : 10.1111 / j.1365-2672.2009.04563.x .
  12. ^ J. Kennedy, SA Jackson, JP Morrissey, F. O'Gara, ADW Dobson: Marine Invertebrate Animal Metagenomics, Porifera. In: Encyclopedia of Metagenomics. Springer, New York City 2013.
  13. ^ SA Jackson, J. Kennedy, LM Margassery, B. Flemer, ND O'Leary, JP Morrissey, F. O'Gara, ADW Dobson: Marine sponges - Molecular Biology and Biotechnology. In: Handbook of Marine Biotechnology. Springer, New York City 2013.
  14. ^ MM Lane, JP Morrissey: Kluyveromyces marxianus : A yeast emerging from its sister's shadow. Fungal Biology Reviews 24 (1), 2010; Pp. 17-26. doi : 10.1016 / j.fbr.2010.01.001 .
  15. ↑ John P. Morrissey, Maria MW Etschmann, Jens Schrader, Gustavo M. de Billerbeck: Cell factory applications of the yeast Kluyveromyces marxianus for the biotechnological production of natural flavor and fragrance molecules. Yeast 32 (1), 2015; Pp. 3-16. doi : 10.1002 / yea.3054 .
  16. Jump up ↑ J. Morrissey, J. Varela, R. Ortiz, K. Wolfe: Adaptation of the yeast Kluyveromyces marxianus to a biotechnological niche. New Biotechnology 44, S7.
  17. ↑ Hannes Juergens, Javier A. Varela, Arthur R. Gorter de Vries, Thomas Perli, Veronica JM Gast, Nikola Y. Gyurchev, Arun S. Rajkumar, Robert Mans, Jack T. Pronk, John P. Morrissey, Jean-Marc G. . Daran: Genome editing in Kluyveromyces and Ogataea yeasts using a broad-host-range Cas9 / gRNA co-expression plasmid. FEMS Yeast Researc 18 (3), 2018; S. foy012. doi : 10.1093 / femsyr / foy012 .
  18. ↑ Official homepage of the "YEASTCELL" project, accessed on April 1, 2019.
  19. ↑ Yeast Cell Factories: Training Researchers to Apply Modern Post-Genomic Methods In Yeast Biotechnology (YEASTCELL) in the CORDIS project database , accessed on April 1, 2019.
  20. ↑ Official homepage of the "YEASTDOC" project, accessed on April 2, 2019.
  21. ↑ Yeast Biotechnology Doctoral Training Program (YEASTDOC) in the CORDIS project database , accessed on April 2, 2019.
  22. ↑ Official homepage of the “CHASSY” project, accessed on April 1, 2019.
  23. ↑ Model-Based Construction And Optimization Of Versatile Chassis Yeast Strains For Production Of Valuable Lipid And Aromatic Compounds (CHASSY) in the CORDIS project database , accessed on April 1, 2019.
  24. ^ Section Board of the European Federation of Biotechnology, accessed April 4, 2019.
  25. ^ Publications by J. Morrissey at Google Scholar; accessed on March 29, 2019.

Web links

personal data
SURNAME Morrissey, John P.
ALTERNATIVE NAMES Morrissey, John Patrick
BRIEF DESCRIPTION Irish microbiologist
DATE OF BIRTH 20th century