Karl Walter Bock

Karl Walter Bock (born  September 8, 1935 in Pforzheim ) is a German pharmacologist and toxicologist . From 1987 to 2000 he was professor and director of the Institute for Toxicology at the Eberhard Karls University in Tübingen , and was particularly dedicated to the regulation and classification of UDP-glucuronosyltransferases . In 2012 he received the Schmiedeberg plaque from the German Society for Experimental and Clinical Pharmacology and Toxicology for his research achievements .

Life

Karl Walter Bock was in 1935 Pforzheim born and initially completed a degree in pharmacy at the Albert-Ludwigs-University of Freiburg , which he with the approval for pharmacists graduated. In addition, he studied in Freiburg and at the Free University of Berlin medicine and attained 1964 in Freiburg medical doctorate . He then worked from 1965 to 1968 with Helmut Holzer as an assistant at the Biochemical Institute of the University of Freiburg, before he worked from 1968 to 1970 at Rockefeller University in New York, among others with the later Nobel Prize winner George Emil Palade .

On his return to Germany he went in 1970 to the Institute of Toxicology at the University of Tübingen , where he Herbert Remmer was hired as an assistant and in 1973 for the Subject "Pharmacology and Toxicology" habilitated . Three years later he took over the management of the "Biochemical Pharmacology" department at the Center for Pharmacology and Toxicology at the Georg-August University of Göttingen , which he held until 1987. In the same year he returned to Tübingen, where he succeeded Herbert Remmer as director of the Institute for Toxicology until his retirement in 2000.

Scientific work

Karl Walter Bock's research focused on the regulation of UDP-glucuronosyltransferases and the classification of the various isoforms of these enzymes , which are essential for the biotransformation of both endogenous substances such as bilirubin and many foreign substances , including drugs such as morphine . In addition, he dealt with the mechanisms of the toxic effects of dioxins . From 1993 to 1997 he was chairman of the toxicology section of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT).

Awards

Karl Walter Bock was elected honorary member of the European Society for Biochemical Pharmacology in 2000. The DGPT awarded him their highest honor in 2012 with the Schmiedeberg plaque .

literature

• Karl Walter Bock: The importance of drug breakdown in the liver. In: Pharmacy in our time . 3 (1) / 1974. Wiley, pp. 35–30, ISSN  1615-1003 (with biographical information on Karl Walter Bock, p. 30)

Further publications

• Karl Walter Bock: Reflections on a Scientific Journey. Publishing house Dr. Hut, Munich 2005, ISBN 3-89-963191-9 (autobiographical memories)

Web links

• Oswald Schmiedeberg plaque 2012 for Karl Walter Bock , German Society for Toxicology (biographical information, with picture)