Klas Kärre

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Klas Kärre (born January 12, 1954 in Strasbourg , France ) is a Swedish physician and immunologist and has been a professor at the Karolinska Institutet since 1993 . His scientific achievements, for which he received the William B. Coley Award and was accepted into the Royal Swedish Academy of Sciences , particularly includes research into the mechanism by which natural killer cells differentiate between healthy cells and virus-infected cells or tumor cells .

Life

Klas Kärre was born in Strasbourg, France , in 1954 and graduated from the Karolinska Institutet with a doctorate in medicine in 1981 . In the mid-1980s, he published the so-called missing-self hypothesis based on the results of his doctoral thesis . This describes how a special group of defense cells of the immune system , the natural killer cells (NK cells), differentiate between healthy endogenous cells and virus-infected cells or tumor cells on the basis of protein structures (signal proteins) on their surface . The recognition of the body's own cells is a central process for the function of the NK cells and thus an important principle within the immune response .

Klas Kärre has been Professor of Molecular Immunology at the Department of Microbiology, Tumor and Cell Biology at the Karolinska Institutet since 1993. Since 2006 he has been a member of the fifteen-member Nobel Committee that selects the winners from the nominations for the Nobel Prize in Physiology or Medicine .

Awards

In 1998 Klas Kärre received the William B. Coley Award for outstanding research in general immunology and tumor immunology, in 2001 the Novartis Prize for general immunology endowed with 100,000 Swiss francs and in 2004 the Avery Landsteiner Prize of the German Society for Immunology . In 2009 he was accepted into the Royal Swedish Academy of Sciences . Since 2002 he has been a full member of the Academia Europaea .

Publications

  • On the immunobiology of natural killer cells. Studies of murine NK cells and their interactions with T cells and T lymphomas . Dissertation, Stockholm University 1981.

Individual evidence

  1. ↑ Klas Kärre: Role of Target Histocompatibility Antigens in Regulation of Natural Killer Activity. A reevaluation and a hypothesis. In: Ronald B. Herbermann, Denis M. Callewaert (Eds.): Mechanisms of NK Cell mediated Cytotoxicity. Academic Press, Orlando 1985, ISBN 0-12-341370-2 , pp. 81-91.
  2. ^ Membership directory: Klas Kärre. Academia Europaea, accessed October 16, 2017 .

Web links

personal data
SURNAME Karre, Klas
BRIEF DESCRIPTION Swedish immunologist
DATE OF BIRTH January 12, 1954
PLACE OF BIRTH Strasbourg , France