Lore Zech

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Lore Zech in her laboratory at the Karolinska Institute, around 1968

Lore Zech (born September 24, 1923 in Gütersloh ; † March 13, 2013 in Sweden ) was a German human geneticist and the developer of the quinacrine or Q banding method.

Life

Lore Zech studied biology, chemistry and physics at the University of Bonn and received her doctorate at the Max Planck Institute in Tübingen . From 1953 to 1989 she researched and taught at the Karolinska Institute in Stockholm, where she founded modern cytogenetics and tumor cytogenetics with the development of the Q-band. Lore Zech retired in 1989 and subsequently worked at the Department of Clinical Genetics in Uppsala. Lore Zech died on March 13, 2013 at the age of 89 in Sweden.

Services

She identified a large number of tumor-specific chromosome changes and thus contributed significantly to the understanding of tumor development. The quinacrine or Q band method made it possible for the first time to display specific band patterns on human chromosomes . It is considered the basis of modern cytogenetics . The method was first presented in 1971 at the IV. International Human Chromosome Conference in Paris. Lore Zech has received numerous awards for her scientific achievements in the field of cytogenetics.

Quinacrine or Q band method

When the German Society for Human Genetics made Lore Zech an honorary member, this was justified, among other things: “Your groundbreaking discovery is the development of staining techniques for chromosome banding, which she had already developed in 1968 and with the help of which a new era of cytogenetic diagnostics began. Her discovery of the Q-band ensured that Lore Zech was ranked 10th among the world's most cited scientists in the years 1965–1978. "

With the help of the chromosome banding technique she developed, Lore Zech identified a large number of tumor-specific chromosome changes and thus contributed significantly to the understanding of tumor development. So z. B. in the Burkitt translocation t (8; 14) (q24; q32) due to the relocation of the oncogene C-MYC located on the long arm of chromosome 8 to the vicinity of the regulatory sequences of the immunoglobulin located on the long arm of chromosome 14 -Schwerketten gene locus permanently upregulates the oncogene C-MYC and thus triggers tumor growth.

Lore Zech described several typical chromosomal changes in chronic lymphocytic leukemia , including the frequent deletion in the long arm of chromosome 13 in chromosome region 13q14. This chromosome aberration was also used to clarify an important molecular mechanism: the loss of a microRNA with subsequent upregulation of an oncogene. Lore Zech paved the way for the molecular characterization of cancer and new therapies in oncology .

Awards

Lore Zech received the Federal Cross of Merit 1st Class in 1991 , an honorary doctorate from the Medical Faculty of the Christian Albrechts University in Kiel, the Mauro Baschirotto Prize from the European Society for Human Genetics, the Björkén Prize from the Medical Faculty of the University of Uppsala, the Gunnar Dahlberg Medal of the Northern Society of Pathology and honorary membership of the European Cytogenetics Association in Vienna. She was the first honorary member of the German Society for Human Genetics. In 1992 she received the Mauro Baschirotto Award (awarded for the first time) by the European Society of Human Genetics .

In her honor, the German Society for Human Genetics established the Lore-Zech Prize for the promotion of somatic tumor genetics and in particular tumor cytogenetics.

Fonts

  • with T. Caspersson , S. Farber, GE Foley, J. Kudynowski, EJ Modest, E. Simonsson and U. Wagh: Chemical differentiation along metaphase chromosomes. In: Experimental Cell Research . 49, 1968, pp. 219-222.
  • Investigation of metaphase chromosomes with DNA-binding fluorochromes. In: Experimental Cell Research. 58, 1969, p. 463.
  • with T. Caspersson, G. Gahrton and J. Lindsten: Identification of the Philadelphia chromosome as a number 22 by quinacrine mustard fluorescence analysis. In: Experimental Cell Research. 63, 1970, pp. 238-240.
  • with T. Caspersson, C. Johansson and EJ Modest: Identification of human chromosomes by DNA-binding fluorescent agents. In: Chromosoma. Volume 30, 1970, pp. 215-227.
  • with T. Caspersson and Lomakka Gösta: The 24 fluorescence patterns of the human metaphase chromosomes - distinguishing characters and variability. In: Hereditas. Volume 67, 1972, pp. 89-102.
  • with G. Gahrton and J. Lindsten: Origin of the Philadelphia chromosome. Tracing of chromosome 22 to parents of patients with chronic myelocytic leukemia. In: Experimental Cell Research. Volume 29, 1973, pp. 246-247.
  • with J. Jonasson, G. Gahrton, J. Lindsten and C. Simonsson-Lindemalm: Trisomy 8 in acute myeloblastic leukemia and sideroachrestic anemia. In: Blood . 43, 1974, pp. 557-563.
  • with G. Gahrton and J. Lindsten: Editorial: The Philadelphia chromosome and chronic myelocytic leukemia (CML) - still a complex relationship? In: Acta Medica Scandinavica. 196, 1974, pp. 353-354.
  • with J. Lindsten, AM Udén and G. Gahrton: Monosomy 7 in two adult patients with acute myeloblastic leukaemia. In: Scandinavian Journal of Hematology. 15, 1975, pp. 251-255.
  • with C. Gahrton, D. Killander, S. Franzén and U. Haglund: Specific chromosomal aberrations in polycythemia vera. In: Blood. 48, 1976, pp. 687-696.
  • with U. Haglund, K. Nilsson and G. Klein: Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas. In: International Journal of Cancer . 17, 1976, pp. 47-56.
  • with G. Gahrton, K. Friberg and J. Lindsten: Duplication of part of the long arm of chromosome 1 in myelofibrosis terminating in acute myeloblastic leukemia. In: Hereditas. 88, 1978, pp. 1-5.
  • with Jonas Bergh, Erik Larsson and Kenneth Nilsson: Establishment and Characterization of Two Neoplastic Cell Lines (U-1285 and U-1568) Derived From Small Cell Carconoma of the Lung. In: Acta Pathologica Microbiologica Scandinavica Series A: Pathology. Volume 90A, No. 1-6, 1982, pp. 149-158, doi: 10.1111 / j.1699-0463.1982.tb00076_90A.x
  • with S. Zhang with G. Klein: High-resolution analysis of chromosome markers in Burkitt lymphoma cell lines. In: International Journal of Cancer. 29, 1982, pp. 153-157.
  • with G. Gahrton, L. Hammarström, G. Juliusson, H. Mellstedt, KH Robèrt and CI Smith: Inversion of chromosome 14 marks human T-cell chronic lymphocytic leukaemia. In: Nature . Volume 308, 1984, pp. 858-860, doi: 10.1038 / 308858a0
  • with G. Juliusson, KH Robèrt, A. Ost, K. Friberg, P. Biberfeld, B. Nilsson and G. Gahrton: Prognostic information from cytogenetic analysis in chronic B-lymphocytic leukemia and leukemic immunocytoma. In: Blood. 65, 1985, pp. 134-141.
  • with H. Mellstedt: Chromosome 13 - a new marker for B-cell chronic lymphocytic leukemia. In: Hereditas. 108, 1988, pp. 77-84.
  • with B. Schlegelberger , H. Euler, H. Löffler, A. Himmler and A. Feller: Appearance of a transient inv (14) (q11q32) in a case of B cell chronic lymphocytic leukemia. In: Cancer Genetics and Cytogenetics. 41, 1989, pp. 87-92.

Web links

Individual evidence

  1. ↑ GfH honorary membership for Prof. Dr. Lore Zech, Uppsala, Sweden.
  2. ↑ Mauro Baschirotto Award , website of the European Society of Human Genetics, accessed on March 1, 2016.
  3. ^ Lore-Zech-Preis , website of the German Society for Human Genetics for the tumor genetic workshop, accessed on March 1, 2016.
personal data
SURNAME Zech, Lore
BRIEF DESCRIPTION German human geneticist
DATE OF BIRTH September 24, 1923
PLACE OF BIRTH Gutersloh
DATE OF DEATH 13th March 2013
Place of death Sweden