Magnesium hydrogen citrate

Structural formula
General
Surname	Magnesium hydrogen citrate
other names	Magnesium citrate, dibasic; Magnesium citrate (ambiguous); Citric acid magnesium salt;
Molecular formula	C 6 H 6 MgO 7
Brief description	white odorless solid
External identifiers / databases
EC number	604-400-1
ECHA InfoCard	100.121.319
PubChem	91886505
Wikidata	Q45044
Drug information
ATC code	A06 AD19 ; A12 CC04 ; B05 CB03 ;
properties
Molar mass	214.4 g mol −1
Physical state	firmly
solubility	soluble in water; Easily soluble in dilute mineral acid; practically insoluble in ethanol 96%; 250 g / l in water (at 100 ° C);
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances Caution
H and P phrases	H: 315-319-335
	P: 261-305 + 351 + 338
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Magnesium hydrogen citrate is a magnesium salt of citric acid . It crystallizes with different contents of crystal water and forms colorless crystals .

properties

Magnesium hydrogen citrate hydrate is a white, odorless solid that is soluble in water. Magnesium compounds reduce nerve and muscle excitability. A loose stool or diarrhea can occur as undesirable effects of magnesium substitution. In the case of extreme overdosing, paralysis of the central nervous system (magnesium anesthesia) can occur - with regard to dosability, a medical distinction is made between parenteral and oral administration, the latter is considered safe because in this way an increase in the magnesium serum concentration only up to 1.1 mmol / l , with a long-term intake for several weeks, is possible. Oral ingestion in excess leads to excretion via the kidneys and intestines (non-pathological diarrhea).

use

Magnesium hydrogen citrate is used in medicine as a laxative . If necessary, it is also taken directly or dissolved in water in order to increase the magnesium ion content in the human body. Preparations can be purchased from the pharmacy without a prescription .

Individual evidence

↑ ^a ^b ^c ^d ^e data sheet containing magnesium hydrogen citrate from Fagron, accessed on December 10, 2017.
↑ Data sheet magnesium citrate (PDF) from Carl Roth , accessed on October 3, 2017.
↑ ^a ^b Data sheet Magnesium citrate from Sigma-Aldrich , accessed on November 5, 2017 ( PDF ).
↑ W. Vierling, D.-H. Liebscher, O. Micke, B. von Ehrlich, K. Kisters: Magnesium deficiency and magnesium therapy for cardiac arrhythmias. In: DMW - German Medical Weekly. 138, 2013, p. 1165, doi : 10.1055 / s-0033-1343206 .
↑ Franz v. Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe: Hager's Handbook of Pharmaceutical Practice, Volume 5: Substances LZ . Springer-Verlag, 2013, ISBN 978-3-642-58388-9 , pp. 86 ( limited preview in Google Book search).

[fagron-1] ↑ ^a ^b ^c ^d ^e data sheet containing magnesium hydrogen citrate from Fagron, accessed on December 10, 2017.

[Roth-2] Data sheet magnesium citrate (PDF) from Carl Roth , accessed on October 3, 2017.

[Sigma-3] Data sheet Magnesium citrate from Sigma-Aldrich , accessed on November 5, 2017 ( PDF ).

[DOI10.1055/s-0033-1343206-4] W. Vierling, D.-H. Liebscher, O. Micke, B. von Ehrlich, K. Kisters: Magnesium deficiency and magnesium therapy for cardiac arrhythmias. In: DMW - German Medical Weekly. 138, 2013, p. 1165, doi : 10.1055 / s-0033-1343206 .

[Franz_v._Bruchhausen,_Siegfried_Ebel,_Eberhard_Hackenthal,_Ulrike_Holzgrabe-5] Franz v. Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe: Hager's Handbook of Pharmaceutical Practice, Volume 5: Substances LZ . Springer-Verlag, 2013, ISBN 978-3-642-58388-9 , pp. 86 ( limited preview in Google Book search).